Caspian Journal of Internal Medicine
Babol University of Medical Sciences
چهارشنبه 1 مهر 1405
[Archive]
دوره 17، شماره 4 - ( 7-1405 )
جلد 17 شماره 4 صفحات 2-0 |
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Wang L, Chen G, Gong P, Ma J, Yu F, Guan B. Expression and clinical significance of TRIM41 in colon cancer. Caspian J Intern Med 2026; 17 (4)
URL: http://caspjim.com/article-1-4875-fa.html
URL: http://caspjim.com/article-1-4875-fa.html
Expression and clinical significance of TRIM41 in colon cancer. . 1405; 17 (4)
چکیده: (77 مشاهده)
Background:Exploring the expression of TRIM41 in colon cancer and its clinical significance.
Methods:Immunohistochemistry EVision method was used to detect the expression of TRIM41 protein in 115 colon cancers and normal tissues adjacent to the cancers, and to analyze its relationship with clinicopathological characteristics of colon cancer; GSEA software was applied to To analyze the related signaling pathway of TRIM41 and immune cell infiltration analysis.
Results:TCGA database showed that TRIM41 was highly expressed in colon cancer (P < 0.001). Survival analysis showed that the overall survival of colon cancer patients with low expression of TRIM41 was significantly higher than that of patients with high expression, and high expression of TRIM41 was associated with poor prognosis of colon cancer patients.X2 test showed that the expression level of TRIM41 was correlated with the degree of tumor differentiation (P=0.002) and the grade of tumor outgrowth (P=0.009) in colon cancer patients.GESA analysis showed that TRIM41 high expression was significantly enriched in signaling pathways such as DNA replication, Fanconi anemia pathway and steroid synthesis. Immunocyte infiltration analysis revealed that the level of CD8+ T-cell infiltration was significantly higher in patients with high TRIM41 expression than in patients with low TRIM41 expression (P=0.01001), and the level of granulocyte infiltration in patients with low expression, was significantly higher than in patients with high expression (P=0.00081).
Conclusion: TRIM41 protein expression is associated with the occurrence and development of colon cancer, and high TRIM41 expression is one of the factors associated with poor prognosis of colon cancer patients.
Methods:Immunohistochemistry EVision method was used to detect the expression of TRIM41 protein in 115 colon cancers and normal tissues adjacent to the cancers, and to analyze its relationship with clinicopathological characteristics of colon cancer; GSEA software was applied to To analyze the related signaling pathway of TRIM41 and immune cell infiltration analysis.
Results:TCGA database showed that TRIM41 was highly expressed in colon cancer (P < 0.001). Survival analysis showed that the overall survival of colon cancer patients with low expression of TRIM41 was significantly higher than that of patients with high expression, and high expression of TRIM41 was associated with poor prognosis of colon cancer patients.X2 test showed that the expression level of TRIM41 was correlated with the degree of tumor differentiation (P=0.002) and the grade of tumor outgrowth (P=0.009) in colon cancer patients.GESA analysis showed that TRIM41 high expression was significantly enriched in signaling pathways such as DNA replication, Fanconi anemia pathway and steroid synthesis. Immunocyte infiltration analysis revealed that the level of CD8+ T-cell infiltration was significantly higher in patients with high TRIM41 expression than in patients with low TRIM41 expression (P=0.01001), and the level of granulocyte infiltration in patients with low expression, was significantly higher than in patients with high expression (P=0.00081).
Conclusion: TRIM41 protein expression is associated with the occurrence and development of colon cancer, and high TRIM41 expression is one of the factors associated with poor prognosis of colon cancer patients.
نوع مطالعه: Review Article |
موضوع مقاله:
Gastroentrology
دریافت: 1404/5/21 | پذیرش: 1405/5/27 | انتشار: 1405/6/18
دریافت: 1404/5/21 | پذیرش: 1405/5/27 | انتشار: 1405/6/18
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