Caspian Journal of Internal Medicine
Babol University of Medical Sciences
یکشنبه 15 شهریور 1405
[Archive]
دوره 17، شماره 3 - ( 4-1405 )
جلد 17 شماره 3 صفحات 554-549 |
برگشت به فهرست نسخه ها
Ethics code: IR.MUBABOL.REC.1401.103
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Akbari R, Mahmoodi Nesheli H, Salehi S, Hajiahmadi M, Sadr Moharerpour S. Serum β2-microglobulin as a marker of renal tubular damage in transfusion-dependent β-thalassemia. Caspian J Intern Med 2026; 17 (3) :549-554
URL: http://caspjim.com/article-1-5063-fa.html
URL: http://caspjim.com/article-1-5063-fa.html
Serum β2-microglobulin as a marker of renal tubular damage in transfusion-dependent β-thalassemia. . 1405; 17 (3) :549-554
چکیده: (11 مشاهده)
Background: β-thalassemia major is a hereditary disorder characterized by transfusion-dependent anemia and associated complications. In patients with β-thalassemia major, one of the long-term complications of regular blood transfusion is renal dysfunction. This study aimed to evaluate serum β2-microglobulin as a marker of the severity of renal tubular dysfunction and to examine the clinical factors associated with the severity of renal tubular dysfunction in children with β-thalassemia major.
Methods: This cross-sectional analytical study was conducted on 134 non-diabetic children with β-thalassemia major who attended thalassemia centers in Mazandaran Province, Iran. Data were collected using a structured checklist that included demographic information, laboratory findings, and clinical parameters. The severity of renal tubular dysfunction was assessed using serum β2-microglobulin levels. Glomerular filtration rate was estimated using the revised Schwartz formula. Pearson correlation analysis was used for statistical analysis.
Results: A significant positive correlation was observed between β2-microglobulin levels and age (r = 0.311, p < 0.001), number of blood transfusions per year (r = 0.390, p < 0.001), serum creatinine (r = 0.732, p < 0.001), blood urea nitrogen (r = 0.715, p < 0.001), and serum ferritin (r = 0.505, p < 0.001). In contrast, significant negative correlations were found with serum hemoglobin (r = −0.433, p < 0.001) and creatinine clearance (r = −0.383, p < 0.001).
Conclusion: Renal tubular dysfunction in children with β-thalassemia major showed significant correlations with age, iron overload, anemia severity, and transfusion frequency. Serum β2-microglobulin may serve as a useful marker for the early detection of tubular damage and may help guide preventive strategies in clinical practice.
Methods: This cross-sectional analytical study was conducted on 134 non-diabetic children with β-thalassemia major who attended thalassemia centers in Mazandaran Province, Iran. Data were collected using a structured checklist that included demographic information, laboratory findings, and clinical parameters. The severity of renal tubular dysfunction was assessed using serum β2-microglobulin levels. Glomerular filtration rate was estimated using the revised Schwartz formula. Pearson correlation analysis was used for statistical analysis.
Results: A significant positive correlation was observed between β2-microglobulin levels and age (r = 0.311, p < 0.001), number of blood transfusions per year (r = 0.390, p < 0.001), serum creatinine (r = 0.732, p < 0.001), blood urea nitrogen (r = 0.715, p < 0.001), and serum ferritin (r = 0.505, p < 0.001). In contrast, significant negative correlations were found with serum hemoglobin (r = −0.433, p < 0.001) and creatinine clearance (r = −0.383, p < 0.001).
Conclusion: Renal tubular dysfunction in children with β-thalassemia major showed significant correlations with age, iron overload, anemia severity, and transfusion frequency. Serum β2-microglobulin may serve as a useful marker for the early detection of tubular damage and may help guide preventive strategies in clinical practice.
نوع مطالعه: Original Article |
موضوع مقاله:
Nephrology
دریافت: 1404/11/12 | پذیرش: 1405/5/26 | انتشار: 1405/3/19
دریافت: 1404/11/12 | پذیرش: 1405/5/26 | انتشار: 1405/3/19
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