Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Wed, Sep 9, 2026
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Volume 17, Issue 3 (Summer 2026)
Caspian J Intern Med 2026, 17(3): 642-652 |
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Akbari R, Abolghasemi S, Shafiekhani M, Asgharpour M, Zare Z, Nikoupour H, et al . Omicron Respiratory Threat in renal transplant recipients. Caspian J Intern Med 2026; 17 (3) :642-652
URL: http://caspjim.com/article-1-4932-en.html
URL: http://caspjim.com/article-1-4932-en.html
Roghayeh Akbari 
, Sara Abolghasemi , Mojtaba Shafiekhani , Masoumeh Asgharpour , Zahra Zare , Hamed Nikoupour , Jamshid Roozbeh , Elmira Mahmoudi Chalmiani , Farshid Oliaie , Mana Baziboroun * , Shiva Nezami
, Sara Abolghasemi , Mojtaba Shafiekhani , Masoumeh Asgharpour , Zahra Zare , Hamed Nikoupour , Jamshid Roozbeh , Elmira Mahmoudi Chalmiani , Farshid Oliaie , Mana Baziboroun * , Shiva Nezami
Infectious Disease and Tropical Medicine Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran. es and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. & Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sci- ences, Babol, I.R. Iran , manabaziboron@gmail.com
Abstract: (17 Views)
Background: Omicron was identified as one of the worrisome strains of corona virus. Renal transplant recipients (RTRs) are classified as high-risk groups due to immunosuppressed conditions. Thus, this study was conducted with the aim of comparing these patients infected with the Omicron variant with the general population infected with this variant compare.
Methods: 62 RTRs infected with the Omicron strain and 60 patients with non-RTRs who were hospitalized from 2021 to 2022 at the peak of Omicron in Tehran, Shiraz and Babol, Iran were included in the study. The two groups were compared regarding clinical findings, laboratory results, pulmonary manifestations on high-resolution computed tomography (HRCT), and adverse effects.
Results: In both groups the most common respiratory symptoms were similar. The ground glass opacity was the most frequent finding on CT scan and was seen in 86 cases (70.5%). There was a reduced absolute lymphocyte count (ALC) and platelet count (85.4% and 41.9%, respectively) in RTRs and the rise of creatinine levels was more in RTRs than those in non-RTRs (79% versus 31.6%). the disease severity (16.1% versus 5%, P = 0.008) and adverse outcomes, such as mechanical ventilation (MV) (12.9% versus 0%, P = 0.004), and the mortality rate was significantly higher in RTRs than the general population.
Conclusion: There was no significant difference in clinical symptoms between two groups except diarrhea. MV, ICU admission and mortality were significantly higher in RTRs under prolonged immunosuppression.
Methods: 62 RTRs infected with the Omicron strain and 60 patients with non-RTRs who were hospitalized from 2021 to 2022 at the peak of Omicron in Tehran, Shiraz and Babol, Iran were included in the study. The two groups were compared regarding clinical findings, laboratory results, pulmonary manifestations on high-resolution computed tomography (HRCT), and adverse effects.
Results: In both groups the most common respiratory symptoms were similar. The ground glass opacity was the most frequent finding on CT scan and was seen in 86 cases (70.5%). There was a reduced absolute lymphocyte count (ALC) and platelet count (85.4% and 41.9%, respectively) in RTRs and the rise of creatinine levels was more in RTRs than those in non-RTRs (79% versus 31.6%). the disease severity (16.1% versus 5%, P = 0.008) and adverse outcomes, such as mechanical ventilation (MV) (12.9% versus 0%, P = 0.004), and the mortality rate was significantly higher in RTRs than the general population.
Conclusion: There was no significant difference in clinical symptoms between two groups except diarrhea. MV, ICU admission and mortality were significantly higher in RTRs under prolonged immunosuppression.
Policy Brief: Original Article |
Subject:
Infectious Diseases
Received: 2025/10/2 | Accepted: 2026/07/1 | Published: 2026/06/9
Received: 2025/10/2 | Accepted: 2026/07/1 | Published: 2026/06/9
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