Caspian Journal of Internal Medicine
Babol University of Medical Sciences
چهارشنبه 18 شهریور 1405
[Archive]
دوره 17، شماره 3 - ( 4-1405 )
جلد 17 شماره 3 صفحات 602-595 |
برگشت به فهرست نسخه ها
Ethics code: IR.MUI.MED.REC.1402.240
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Bahrami S, Ramezani N, Yazdanpanah M, Vaheb S, Mirmosayyeb O, Davanian F, et al . Thalamic Atrophy in Active and Inactive Secondary Progressive Multiple Sclerosis Patients: A Comparative Study. Caspian J Intern Med 2026; 17 (3) :595-602
URL: http://caspjim.com/article-1-4915-fa.html
URL: http://caspjim.com/article-1-4915-fa.html
Thalamic Atrophy in Active and Inactive Secondary Progressive Multiple Sclerosis Patients: A Comparative Study. . 1405; 17 (3) :595-602
چکیده: (24 مشاهده)
Background: Thalamic atrophy may be an indicator of neurodegeneration in people with secondary progressive multiple sclerosis (pwSPMS). The atrophy usually begins asymmetrically, and the thalamic asymmetry index (TAI) can be used to estimate the severity of neurodegeneration. SPMS is commonly divided into two groups of active and inactive. No study has compared TAI between SPMS groups and examine its relationships with cognitive and motor measures in pwSPMS. This study aimed to compare the TAI between active and inactive pwSPMS and to examine its relationship with key clinical, cognitive, and motor variables.
Methods: In this cross-sectional study, 38 pwSPMS (15 active and 23 inactive) were enrolled from February to November 2024. MRI-based volumetric measurements were used to determine thalamic volumes and calculate the TAI. Cognitive and motor tests, including the SDMT, PASAT, and 9HPT were also administered alongside clinical examinations.
Results: Active SPMS patients had significantly lower NTV compared to inactive patients (Cohen’s d = -1.58, p < 0.001). No significant difference in TAI was observed between groups. NTV correlated with cognitive scores in both active (r = 0.74, P = 0.002) and inactive (r = 0.65, p < 0.001) groups and with disability in the inactive group (r = -0.5, P= 0.014). Active SPMS patients showed worse cognitive and motor performance.
Conclusion: Thalamic atrophy is more severe in active SPMS and is associated with worse cognitive and motor outcomes. While thalamic asymmetry did not differentiate between subgroups, it may serve as a marker for functional status in SPMS.
Methods: In this cross-sectional study, 38 pwSPMS (15 active and 23 inactive) were enrolled from February to November 2024. MRI-based volumetric measurements were used to determine thalamic volumes and calculate the TAI. Cognitive and motor tests, including the SDMT, PASAT, and 9HPT were also administered alongside clinical examinations.
Results: Active SPMS patients had significantly lower NTV compared to inactive patients (Cohen’s d = -1.58, p < 0.001). No significant difference in TAI was observed between groups. NTV correlated with cognitive scores in both active (r = 0.74, P = 0.002) and inactive (r = 0.65, p < 0.001) groups and with disability in the inactive group (r = -0.5, P= 0.014). Active SPMS patients showed worse cognitive and motor performance.
Conclusion: Thalamic atrophy is more severe in active SPMS and is associated with worse cognitive and motor outcomes. While thalamic asymmetry did not differentiate between subgroups, it may serve as a marker for functional status in SPMS.
نوع مطالعه: Original Article |
موضوع مقاله:
Neurology
دریافت: 1404/6/22 | پذیرش: 1404/10/30 | انتشار: 1405/3/19
دریافت: 1404/6/22 | پذیرش: 1404/10/30 | انتشار: 1405/3/19
| بازنشر اطلاعات | |
 |
این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است. |
