Caspian Journal of Internal Medicine
Babol University of Medical Sciences
شنبه 21 شهریور 1405
[Archive]
دوره 17، شماره 3 - ( 4-1405 )
جلد 17 شماره 3 صفحات 687-681 |
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Ruiz-Huaranga E G, Quinones Avila M D P, Marcilla Truyenque R L, Concepcion-Zavaleta M J, Paz-Ibarra J, Fuentes-Mendoza J et al . First case report of ectopic Cushing's syndrome secondary to synchronous mediastinal neuroendocrine tumors. Caspian J Intern Med 2026; 17 (3) :681-687
URL: http://caspjim.com/article-1-4832-fa.html
URL: http://caspjim.com/article-1-4832-fa.html
First case report of ectopic Cushing's syndrome secondary to synchronous mediastinal neuroendocrine tumors. . 1405; 17 (3) :681-687
چکیده: (25 مشاهده)
Background: Ectopic Cushing's syndrome (ECS) is a rare cause of hypercortisolism resulting from non-pituitary adrenocorticotropic hormone (ACTH) secretion, most associated with neuroendocrine tumors (NETs) of pulmonary or gastrointestinal origin. Mediastinal NETs are an extremely rare source.
Case Presentation: We report the case of a 23-year-old male with no relevant medical history, presenting with progressive muscle weakness, hyperpigmentation, weight gain, and signs of severe hypercortisolism, including moon facies, ecchymosis, hypertension, hyperglycemia, and hypokalemia. Hormonal tests confirmed ECS with markedly elevated ACTH and cortisol levels. Imaging revealed two anterior mediastinal masses. Histopathological analysis of the surgical specimens confirmed ACTH-producing atypical NETs.
Conclusions: This case highlights the importance of considering ectopic ACTH secretion from mediastinal neuroendocrine tumors in the differential diagnosis of severe, rapidly progressive hypercortisolism. Early recognition and timely surgical management can prevent life-threatening complications and improve patient outcomes, even in rare and aggressive presentations.
Case Presentation: We report the case of a 23-year-old male with no relevant medical history, presenting with progressive muscle weakness, hyperpigmentation, weight gain, and signs of severe hypercortisolism, including moon facies, ecchymosis, hypertension, hyperglycemia, and hypokalemia. Hormonal tests confirmed ECS with markedly elevated ACTH and cortisol levels. Imaging revealed two anterior mediastinal masses. Histopathological analysis of the surgical specimens confirmed ACTH-producing atypical NETs.
Conclusions: This case highlights the importance of considering ectopic ACTH secretion from mediastinal neuroendocrine tumors in the differential diagnosis of severe, rapidly progressive hypercortisolism. Early recognition and timely surgical management can prevent life-threatening complications and improve patient outcomes, even in rare and aggressive presentations.
نوع مطالعه: case report |
موضوع مقاله:
Endocrinology
دریافت: 1404/4/25 | پذیرش: 1404/6/16 | انتشار: 1405/4/8
دریافت: 1404/4/25 | پذیرش: 1404/6/16 | انتشار: 1405/4/8
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