Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Mon, Feb 2, 2026
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Volume 17, Issue 1 (Winter 2026)
Caspian J Intern Med 2026, 17(1): 205-210 |
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Ethics code: Of. N: 894-2024-UNT-FM-C.E.
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Paz-Ibarra J, Herrera Silvestre H, Lúcar Siu G A, Del Carpio Reymer G, Cubas Llalle W, Concepción-Zavaleta M, et al . Acromegalic features and hypoglycemia: Doege-Potter syndrome. Caspian J Intern Med 2026; 17 (1) :205-210
URL: http://caspjim.com/article-1-4641-en.html
URL: http://caspjim.com/article-1-4641-en.html
José Paz-Ibarra 
, Hilder Herrera Silvestre , Gianella Andrea Lúcar Siu , Gianfranco Del Carpio Reymer , Wildor Cubas Llalle , Marcio Concepción-Zavaleta , Luis Concepción-Urteaga * , Juan Eduardo Quiroz-Aldave , Joseph Arzapalo Benavides , José Somocurcio Peralta
, Hilder Herrera Silvestre , Gianella Andrea Lúcar Siu , Gianfranco Del Carpio Reymer , Wildor Cubas Llalle , Marcio Concepción-Zavaleta , Luis Concepción-Urteaga * , Juan Eduardo Quiroz-Aldave , Joseph Arzapalo Benavides , José Somocurcio Peralta
School of Medicine, Universidad Nacional de Trujillo. Trujillo, Perú. , lconcepcion@unitru.edu.pe
Abstract: (85 Views)
Background: Doege-Potter syndrome (DPS) is a condition characterized by severe, symptomatic, and sustained hypoglycemia, refractory to medical treatment, due to non-insular tumor cells.
Case Presentation: We describe the case of a 73-year-old male with acromegalic features and two months of hypoglycemic episodes, in whom a giant mass was identified in the right hemithorax via radiography. Surgical resection of the tumor resolved hypoglycemia and improved the acromegalic traits.
Solitary fibrous tumors (SFTs) are rare neoplasms that predominantly affect individuals aged 50 to 60 years. Doege-Potter syndrome is a cause of hypoglycemia, present in 2-4% of SFT cases. Its manifestations arise from abnormal synthesis and secretion of insulin-like growth factor (IGF)-2 by the SFT. In rare instances, patients with DPS may exhibit signs of acromegaly, attributed to the stimulation of the IGF-1 receptor by IGF-2. The initial diagnostic approach to DPS includes imaging and hormonal studies, while the definitive diagnosis is made through histopathology.
Conclusions: We emphasize the importance of considering DPS in patients with thoracic tumors and persistent hypoglycemia, especially when accompanied by acromegalic features.
Case Presentation: We describe the case of a 73-year-old male with acromegalic features and two months of hypoglycemic episodes, in whom a giant mass was identified in the right hemithorax via radiography. Surgical resection of the tumor resolved hypoglycemia and improved the acromegalic traits.
Solitary fibrous tumors (SFTs) are rare neoplasms that predominantly affect individuals aged 50 to 60 years. Doege-Potter syndrome is a cause of hypoglycemia, present in 2-4% of SFT cases. Its manifestations arise from abnormal synthesis and secretion of insulin-like growth factor (IGF)-2 by the SFT. In rare instances, patients with DPS may exhibit signs of acromegaly, attributed to the stimulation of the IGF-1 receptor by IGF-2. The initial diagnostic approach to DPS includes imaging and hormonal studies, while the definitive diagnosis is made through histopathology.
Conclusions: We emphasize the importance of considering DPS in patients with thoracic tumors and persistent hypoglycemia, especially when accompanied by acromegalic features.
Policy Brief: case report |
Subject:
Endocrinology
Received: 2024/12/28 | Accepted: 2025/04/14 | Published: 2026/01/1
Received: 2024/12/28 | Accepted: 2025/04/14 | Published: 2026/01/1
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