Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, May 28, 2026
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Volume 17, Issue 2 (Spring 2026)
Caspian J Intern Med 2026, 17(2): 15-0 |
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Ethics code: IR.UMSU.REC.1400.034
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Sadri M, Masudi S, Farshid S, Nemati Oskuii M. The correlation between survival with clinical and pathological features of renal cancer patients after surgical intervention. Caspian J Intern Med 2026; 17 (2) :15-0
URL: http://caspjim.com/article-1-4600-en.html
URL: http://caspjim.com/article-1-4600-en.html
Department of Urology, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran , drsadrihkc@gmail.com
Abstract: (77 Views)
Background: Renal cell carcinoma (RCC) is a prevalent malignancy with a steadily increasing incidence. This study examined the association between clinical and pathological factors and RCC patient survival outcomes.
Methods: This cross-sectional study enrolled patients diagnosed with malignant renal tumors who underwent surgical resection at Urmia Imam Khomeini Hospital between April 2017 and March 2022. Eligible patients were identified through a review of medical records and recruited using a convenience sampling method. Demographic, clinical, and pathological data were collected for each patient.
Results: Of the 171 patients, 104 were male and 67 were female with a mean age of 57.9 years (SD ±14.5). The one-, three, and five-year overall survival rates were 84.7%, 72.4%, and 70.5%, respectively. Univariate regression analysis revealed that five-year mortality following surgical intervention was strongly associated with moderate-to-severe anemia (HR 15.661, 95% CI 6.880-35.651, p < 0.001), elevated ESR (>50; HR 14.172, 95% CI 5.370-37.404, p < 0.001), presence of necrosis (HR 13.216, 95% CI 5.213-33.509, p < 0.001), and lymphovascular invasion (HR 7.988, 95% CI 4.184-15.251, p < 0.001). Multivariate regression analysis identified moderate-to-severe anemia, lymphovascular invasion, and large tumor size as strong predictors of five-year mortality. Conversely, the absence of anemia, lymphovascular invasion, and smaller tumor size (<6 cm) were associated with a lower mortality risk and improved survival. Overweight and obese patients exhibited a lower risk of mortality.
Conclusion: These findings highlight the importance of considering clinical and pathological features in the management and prognosis of RCC patients.
Methods: This cross-sectional study enrolled patients diagnosed with malignant renal tumors who underwent surgical resection at Urmia Imam Khomeini Hospital between April 2017 and March 2022. Eligible patients were identified through a review of medical records and recruited using a convenience sampling method. Demographic, clinical, and pathological data were collected for each patient.
Results: Of the 171 patients, 104 were male and 67 were female with a mean age of 57.9 years (SD ±14.5). The one-, three, and five-year overall survival rates were 84.7%, 72.4%, and 70.5%, respectively. Univariate regression analysis revealed that five-year mortality following surgical intervention was strongly associated with moderate-to-severe anemia (HR 15.661, 95% CI 6.880-35.651, p < 0.001), elevated ESR (>50; HR 14.172, 95% CI 5.370-37.404, p < 0.001), presence of necrosis (HR 13.216, 95% CI 5.213-33.509, p < 0.001), and lymphovascular invasion (HR 7.988, 95% CI 4.184-15.251, p < 0.001). Multivariate regression analysis identified moderate-to-severe anemia, lymphovascular invasion, and large tumor size as strong predictors of five-year mortality. Conversely, the absence of anemia, lymphovascular invasion, and smaller tumor size (<6 cm) were associated with a lower mortality risk and improved survival. Overweight and obese patients exhibited a lower risk of mortality.
Conclusion: These findings highlight the importance of considering clinical and pathological features in the management and prognosis of RCC patients.
Policy Brief: Original Article |
Subject:
Nephrology
Received: 2024/11/28 | Accepted: 2025/09/22 | Published: 2026/03/24
Received: 2024/11/28 | Accepted: 2025/09/22 | Published: 2026/03/24
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