Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Thu, Jun 26, 2025
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Volume 16, Issue 3 (Summer 2025)
Caspian J Intern Med 2025, 16(3): 525-535 |
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Rana K, Chavda T K, Chavda S, Sonkar C, Soni K, Patel K, et al . Serum fibrinogen & total cholesterol: A significant primary biomarker and its interrelationship in stroke. Caspian J Intern Med 2025; 16 (3) :525-535
URL: http://caspjim.com/article-1-4063-en.html
URL: http://caspjim.com/article-1-4063-en.html
Komal Rana 
, Tarun Kumar Chavda , Sonal Chavda , Chetan Sonkar * , Krishna Soni , Krina Patel , Nancy Vaja , Sanjay Vahora , Amal Kumar Bhattacharya
, Tarun Kumar Chavda , Sonal Chavda , Chetan Sonkar * , Krishna Soni , Krina Patel , Nancy Vaja , Sanjay Vahora , Amal Kumar Bhattacharya
Department of Medicine, Parul Sevashram Hospital (PSH), Parul Institute of Medical Sciences and Research (PIMSR), Parul University, Vadodara, Gujarat, India , chetansonkar111@gmail.com
Abstract: (61 Views)
Background: To study the association of plasma fibrinogen & total cholesterol levels, incidences, prevalence, and gender wise distribution in different etiologies of stroke.
Methods: Fibrinogen & total cholesterol levels, prevalence, incidences, comorbidities, and different etiologies were assessed along with routine investigations and radiology inputs as per investigator’s discretion. The overall median values were represented in graphically format in MS-Excel.
Results: 292 Males: 218 females. Age 30 to 80 years. Among, 25.1% diabetic, 38.9 % hypertension (HTN) and 31% diabetes + HTN. 5 % diabetes + HTN + dyslipidemia and other comorbidities. Overall, 73% had ischemic stroke (IS) & 27 % have hemorrhagic stroke (HS). Hemiparesis in 76.5 %. Mean Fibrinogen elevated in 81% and range was 934±20 mg/dL. Total cholesterol level increased in 73.2% & range was 365±10 mg/dL. The HS patients were experienced headache 77 (19.60%) and vomiting 34 (24.6%) than IS patients. As per radiological finding, the territory of Middle Cerebral Artery was the ordinary location of arterial territory infarctions in the IS form that was present in 213 (57.2%) subjects following that in the anterior side of cerebral artery in 89 (23.92%) and posterior cerebral artery was 44 (11.82%). Arterial flutter found in 56 (10.9%), Structural heart disease present in 30 (5.88%), family history of stroke in 28 (5.49%).
Conclusion: Elevated fibrinogen & total cholesterol levels are independent significant primary biomarkers elevated with incidences of CV stroke. Stroke was higher in ischemic stroke group.
Methods: Fibrinogen & total cholesterol levels, prevalence, incidences, comorbidities, and different etiologies were assessed along with routine investigations and radiology inputs as per investigator’s discretion. The overall median values were represented in graphically format in MS-Excel.
Results: 292 Males: 218 females. Age 30 to 80 years. Among, 25.1% diabetic, 38.9 % hypertension (HTN) and 31% diabetes + HTN. 5 % diabetes + HTN + dyslipidemia and other comorbidities. Overall, 73% had ischemic stroke (IS) & 27 % have hemorrhagic stroke (HS). Hemiparesis in 76.5 %. Mean Fibrinogen elevated in 81% and range was 934±20 mg/dL. Total cholesterol level increased in 73.2% & range was 365±10 mg/dL. The HS patients were experienced headache 77 (19.60%) and vomiting 34 (24.6%) than IS patients. As per radiological finding, the territory of Middle Cerebral Artery was the ordinary location of arterial territory infarctions in the IS form that was present in 213 (57.2%) subjects following that in the anterior side of cerebral artery in 89 (23.92%) and posterior cerebral artery was 44 (11.82%). Arterial flutter found in 56 (10.9%), Structural heart disease present in 30 (5.88%), family history of stroke in 28 (5.49%).
Conclusion: Elevated fibrinogen & total cholesterol levels are independent significant primary biomarkers elevated with incidences of CV stroke. Stroke was higher in ischemic stroke group.
Type of Study: Original Article |
Subject:
Cardiology
Received: 2023/08/27 | Accepted: 2024/06/1 | Published: 2025/06/20
Received: 2023/08/27 | Accepted: 2024/06/1 | Published: 2025/06/20
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