en Infectious Diseases Infectious Diseases Original Article Original Article <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Septimeb as a herbal medicine has regulatory effects on inflammation. This study set to evaluate the effects of Septimeb among patients with sepsis on inflammatory biomarkers and survival rate.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> In this randomized clinical trial, 51 patients with sepsis from the ICU and medical ward of Imam Khomeini Hospital were divided into two groups: Septimeb (n=25) and control group (n=26). In the control group, the patients received a standard treatment only for 7 days, while Septimeb group received Septimeb (6cc vial with 500cc serum glucose infusion 5% daily for one to two hours) plus standard treatment of sepsis for 7 days. Then, blood samples were analyzed. APACHE (Acute Physiologic and Chronic Health Evaluation), SOFA (Sequential Organ Failure Assessment), and GCS (Glasgow Coma Score) values were calculated daily.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> Treatment with Septimeb showed a significant decrease in SOFA value (1.54&plusmn;0.83) compared to the control group (2.39&plusmn;0.88) (P<0.001) and a significant increase in GCS value (14.46&plusmn;0.88) compared to the control group (12.86&plusmn;1.78) (P<0.001).&nbsp; Improvements of these values can confirm the potential of Septimeb in the reduction of severity of sepsis (P<0.05). There were significant decreases in lactate and blood sugar and WBC levels. In addition, inflammatory factors such as ESR (Septimeb group: 52.07&plusmn;34.80, control group: 51.75&plusmn;42.10, P=0.98) and CRP (Septimeb group: 48.86&plusmn;23.21, control group: 49.93&plusmn;36.22, P=0.92) decreased, but did not show a significant reduction.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>Septimeb has positive effects on reduction of the severity of sepsis which leads to reduction of patients&rsquo; mortality rates.</span></p> Sepsis, Septimeb, Infection, Inflammatory 35 43 http://caspjim.com/browse.php?a_code=A-10-532-1&slc_lang=en&sid=1 Alieh Pourdast dr_apourdast@yahoo.com 10031947532846007440 10031947532846007440 No Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Science, Tehran Maryam Sanaie sanaeimaryam@gmail.com 10031947532846007441 10031947532846007441 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Sirous Jafari jafari@gmail.com 10031947532846007442 10031947532846007442 No Department of Infectious and Tropical Diseases, Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Mostafa Mohammadi Mohammadi@gmail.com 10031947532846007443 10031947532846007443 No Department of Anesthesiology and critical care medicine, , Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Hossein Khalili Khalili@gmail.com 10031947532846007444 10031947532846007444 No Department of pharmacotherapy , Imam Khomeini Hospital Complex, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Gita Shafiee gshafiee.endocrine@gmail.com 10031947532846007445 10031947532846007445 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Zeinab Ahadi zeinab_ad@yahoo.com 10031947532846007446 10031947532846007446 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Mahsa Rostami mahsa_rstm@yahoo.com 10031947532846007447 10031947532846007447 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Saba Alizad Alizad@gmail.com 10031947532846007448 10031947532846007448 No Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Ramin Heshmat ahadi.ze@gmail.com 10031947532846007449 10031947532846007449 Yes Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran Minoo Mohraz minoomohraz@ams.ac.ir 10031947532846007450 10031947532846007450 No Iranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Science, Tehran