en Neurology Neurology Original Article Original Article <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Headache and depression are prevalent among general population. The aim of this study was to determine the associated factors of headache in elderly subjects with emphasis to depression.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> All cohort of elderly individuals of the Amirkola Health Study Project were included. Data regarding several clinical and demographic characteristics were provided via fill in quesstionnaire, interview and clinical examination. Presence and duration as well as severity of headache were collected through an interview based on self-reported data. Diagnosis of depression was confirmed according to standard Geriatric Depression Scale (GDS) criteria. In statistical analyses chi-square test with logistic regression analysis was used for association.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> A total of 832 men and 667 women aged >/= 60 years old were studied. Headache and depression were diagnosed in 42% and 42.4% respectively. In depressed subjects, headache was significantly higher by OR=3.1(95% CI, 2.5-3.83, P=0.001). Proportions of headache increased by severity of depression with a dose-response pattern of relationship from 53.3% in mild depression to 72.6% in severe depression. The magnitude of OR for headache increased from 2.59 (95% CI, 2.03-3.31) in patients with mild depression to 6.04 (95% CI, 3.54-10.3) in patients with severe depression. After adjustment for all covariates, headache was significantly associated with female gender and back pain as well as with depression with a significant dose-response relationship.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion:</em></strong></span> The findings of this study indicated an independent association between headache and psychological factors in elderly subjects, particularly in women</span></p> Depression, Elderly subjects, Headache, Pain 120 125 http://caspjim.com/browse.php?a_code=A-10-88-2&slc_lang=en&sid=1 Alijan Ahmadiahangar ahmadiahangaralijan@yahoo.com 10031947532846005380 10031947532846005380 Yes Mobility impairment research centre, , Babol University of Medical Sciences, Babol, Iran seyyed-reza Hoseyni hosseinirezaseyed@gmail.com 10031947532846005381 10031947532846005381 No Department of Biometric and Epidemiology Farzan Kheyrkhah drfarzankh@yahoo.com 10031947532846005382 10031947532846005382 No Department of psychiatry, Babol University of Medical Sciences, Babol, Iran Ali Bijani alibijani@yahoo.com 10031947532846005383 10031947532846005383 No , Babol University of Medical Sciences, Babol, Iran Zahra Moghaddas zahramoghadas@yahoo.com 10031947532846005384 10031947532846005384 No , Babol University of Medical Sciences, Babol, Iran