en Imonology Imonology Original Article Original Article <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>In this study, we determined the serum levels of IL-17A and IL-10 in context with 1, 2 dihydroxy vitamin D3, parathormone and Ca²⁺/Pi ions to investigate their pathological or protective roles respectively in bone metabolism.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> The bone mineral density (BMD) was determined for 1203 participants using energy X-ray absorptiometry. Subjects with a history of diseases and using bone metabolism medications were excluded and finally serum IL-10 was measured in 82 osteoporotic and 74 healthy individuals (mean age &plusmn;SD of 71.04&plusmn;6.9 and 68.58&plusmn;6.9 respectively). Also, the serum level of IL-17A was assessed in 42 osteoporotic and 39 non-osteoporotic subjects (mean age&plusmn;SD of 69.40&plusmn;6.7 and 70.77&plusmn;7.1, respectively). Serum levels of 1, 25-dihydroxyvitamin D3, Ca²⁺/Pi ions and parathormone were extracted from AHAP cohort data bank.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> IL-17A was detectable in 7.42(16.67%) osteoporotic subjects and 3.39(7.69%) normal subjects. Surprisingly, patient subjects exhibited a higher level of serum IL-10 than normal subjects (P=0.023). We found that the serum parathormone levels tend to increase in patient group (P=0.003) in comparison to normal control with no correlation with Il-10 levels. There was no significant difference between the two groups in the serum levels of 1, 25-dihydroxyvitamin D3, Ca²⁺and P_i ions.</span></p> <p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>In reaction to chronic inflammation old osteoporotic patients independent of 1, 25 dihydroxy vitamin D3 may produce a higher level of IL-10 to dampen production of inflammatory cytokines including IL-17A which in turn leads to speeding up parathormone production ultimately reaching a new homeostasis status in bone metabolism with normal serum Ca²⁺ /Pi ions.</span></p> Osteoporosis, IL-10, IL-17A, Parathormone, 1, 25dihydroxy vitamin D3, Elderly 283 289 http://caspjim.com/browse.php?a_code=A-10-146-1&slc_lang=en&sid=1 Mohamad Teimorian teimorianm@gmail.com 10031947532846006810 10031947532846006810 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran. Zeinab Jafarian teimorianm@gmail.com 10031947532846006811 10031947532846006811 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran. Seyed-Reza Hosseyni hosseinirezaseyed@gmail.com 10031947532846006812 10031947532846006812 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran. Mahsa Rahmani teimorianm@gmail.com 10031947532846006813 10031947532846006813 No Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Mojgan Bagherzadeh mojan73@yahoo.com 10031947532846006814 10031947532846006814 No Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Azin Aghmajidi teimorianm@gmail.com 10031947532846006815 10031947532846006815 No Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Ali Bijani alibijani@yahoo.com 10031947532846006816 10031947532846006816 No Non-Communicable Pediatrics Diseases Research Center, Health Research institute, Babol University of Medical Sciences, Babol, Iran. Hajighorban Nooreddini teimorianm@gmail.com 10031947532846006817 10031947532846006817 No Departent of Radiology, Faculty of Medicine, Babol University of Medical Sciences, Babol,Iran Amrollah Mostafazadeh amrolah65@yahoo.com 10031947532846006818 10031947532846006818 Yes Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.