en Obstetrics & Gynicology Obstetrics & Gynicology Original Article Original Article <p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Research says that diabetes may develop in over 10% of non-diabetic pregnant women. Diabetes which generally occurs late in second trimester and third trimester of pregnancy, it is called gestational diabetes. Overweight or suffering from obesity before pregnancy is type 2 diabetes risk factor. In most cases, diabetic symptoms disappear after delivery. HLA-G has an important role both in mother and fetus tolerance during pregnancy, it may also be effective in the protection of pancreatic islet cells. In this study, concentration of these molecules in pregnant women with gestational diabetes in comparison with normal pregnant women was investigated.</span></p> <p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> In this case-control study, we measured serum HLA-G levels in 24 pregnant women with gestational diabetes compared with 30 normal pregnant women using sandwich ELISA.</span></p> <p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> HLA-G levels were significantly low in pregnant women with gestational diabetes&nbsp;&nbsp; in contrast to normal pregnant women (P=0.001).</span></p> <p style="margin-left: 161.6pt;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>In this study, we found that HLA-G levels were reduced in women with gestational diabetes compared with control group. Therefore, it is suggested that measurement of HLA-G in pregnant women can be considered as an indicator in prognosis of gestational diabetes.</span></p> HLA-G, gestational diabetes, pregnancy 178 182 http://caspjim.com/browse.php?a_code=A-10-391-1&slc_lang=en&sid=1 Saeide-Sadat Shobeiri setare@yahoo.com 10031947532846005963 10031947532846005963 No Department of Immunology , Immunogenetic Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Saeid Abediankenari abedianlab@yahoo.co.uk 10031947532846005964 10031947532846005964 Yes Immunogetics Research Center , Mazandaran University of Medical Sciences, Sari, Iran Bahareh Lashtoo aghaee bahareh@yahoo.com 10031947532846005965 10031947532846005965 No Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Zahra Rahmani rahmani@yahoo.com 10031947532846005966 10031947532846005966 No Immunogenetics Research Center, Mazandaran University of Medical Sciences, sari, Iran. Bahareh Esmaeili-Gorji bBatool@yahoo.com 10031947532846005967 10031947532846005967 No Department of Biology, Qaemshahr branch, Islamic Azad University, Qaemshahr, Iran.