en مقایسه اثر آرامبخشی اتومیدیت –فنتانیل و پروپوفول – فنتانیل در بیماران کاندید کولونوسکوپی :یک مطالعه تصادفی آینده نگر Infectious Diseases Infectious Diseases Original Article Original Article Abstract Background: The combination of propofol-fentanyl for sedation during colonoscopy is characterized by the frequent incidence of side effects. Etomidate-fentanyl provides fewer hemodynamic and respiratory complications. The aim of our study was to compare the safety and efficacy of propofol-fentanyl and etomidate-fentanyl for conscious sedation in elective colonoscopy. Methods: This double-blind clinical trial was conducted on 90 patients aged between 18 and 55 years old who were candidates for elective colonoscopy. Patients were randomized to receive sedation with fentanyl plus propofol or etomidate. Two minutes after injecting 1 micro/kg of fentanyl, the patients received propofol (0.5 mg/kg followed 25 micro/kg/min) or etomidate (0.1 mg/kg followed 15 micro/kg/min). Pulse rate, mean arterial blood pressure, respiratory rate, and saturation of peripheral oxygen (SPO2) were monitored. Indeed, the patient and colonoscopist satisfaction, the recovery time, sedation and pain score in both groups were assessed. Results: Sedation score in propofol group was higher. Pain score as well as the physician and patient satisfaction showed no significant difference in two study groups. Hemodynamic changes and arterial saturation were the same in both groups. The duration of recovery was 1.27±0.82 minutes in the etomidate group whereas, it was 2.57±2.46 minutes in the propofol group (P=0.001). Hospital discharge in the propofol group was 5.53±4.67 minutes and in the etomidate group was 2.68±3.14 minutes (p=0.001). Conclusion: The combination of fentanyl and etomidate provides an acceptable alternative to sedation with fentanyl and propofol with the advantage of significantly faster recovery time, which are of relevance in the outpatient setting. propofol, etomidate, colonoscopy, sedation 15 19 http://caspjim.com/browse.php?a_code=A-10-48-1&slc_lang=en&sid=1 Nadia Banihashem نادیا بنی هاشم nbanihashem@yahoo.com 10031947532846002775 10031947532846002775 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Ebrahim Alijanpour ابراهیم علیجانپور dralijanpour@yahoo.com 10031947532846002776 10031947532846002776 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Majid Basirat مجید بصیرت 10031947532846002777 10031947532846002777 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Javad Shokri جواد شکری 10031947532846002778 10031947532846002778 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Mehrdad Kashifard مهرداد کاشی فرد 10031947532846002779 10031947532846002779 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Seyed Hasan Taheri سید حسن طاهری 10031947532846002780 10031947532846002780 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Shahryar Savadkohi شهریار سوادکوهی 10031947532846002781 10031947532846002781 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل Vahid Hosseini وحید حسینی dr.vahid47@gmail.com 10031947532846002782 10031947532846002782 Yes Mazandaran University of Medical Sciences دانشگاه علوم پزشکی مازندران seyed sedigheh solimanian سید صدیقه سلیمانیان ans_dep@yahoo.com 10031947532846002783 10031947532846002783 No Babol University of Medical Sciences دانشگاه علوم پزشکی بابل