Caspian Journal of Internal Medicine

en Pulse Wave Velocity as a Non-Invasive Discriminative Marker of Bone Health in Postmenopausal Women Internal Internal Original Article Original Article Background: Increased arterial stiffness has been linked to osteoporosis. This study evaluates Pulse Wave Velocity (PWV) as a discriminator of osteopenia and osteoporosis at the lumbar spine and femoral neck in postmenopausal women. Methods: In this cross-sectional study, arterial stiffness and bone mineral density (BMD) at the spine and femoral neck were assessed using carotid-to-femoral Pulse PWV and dual-energy x-ray absorptiometry (DXA). Eighteen premenopausal women (mean age 41.30±4.30 years) and forty-eight postmenopausal women (mean age 59.40±9.10 years) participated in the study. Osteoporosis (T-score ≤-2.5) and osteopenia (-2.5< T-score ≤-1) were defined by T-score criteria. Results: Pearson's correlation results showed: PWV and femoral neck BMD (r = -0.439, P = 0.002), PWV and spine BMD (r =-0.358, P = 0.012), and PWV and menopausal duration (r = 0.381, P = 0.008). PWV demonstrated significant discriminative ability for femoral neck osteopenia [b = 0.6472, Wald = 5.717, Odds ratio (OR) = 1.910, P = 0.017, Area Under Curve (AUC) = 0.704], femoral neck osteoporosis (b = 0.7206, Wald = 5.838, OR = 2.056, P = 0.016, AUC = 0.758), spine osteopenia (b = 0.8489, Wald = 5.639, OR = 2.337, P = 0.018, AUC = 0.677), and spine osteoporosis (b = 1.0829, Wald = 8.269, OR = 2.953, P = 0.004, AUC = 0.804). Conclusion: PWV was inversely correlated with femoral neck and spine BMD, and positively correlated with menopausal duration. It serves as a significant discriminator of bone health, indicating increased odds of osteopenia and osteoporosis.   Pulse Wave Velocity, Arterial Stiffness, Bone Mineral Density, Osteoporosis, Dual-energy X-ray absorptiometry, Menopause. 622 632 http://caspjim.com/browse.php?a_code=A-10-1189-4&slc_lang=en&sid=1 Maja Avramovska dr.avramovska@gmail.com 100319475328460057879 100319475328460057879 No University “St Kliment Ohridski” Bitola, Clinical Hospital - Bitola, Department of Gynecology and Obstetrics, Bitola, North Macedonia Zorica Nikleski zorica_marjanovik@hotmail.com 100319475328460057880 100319475328460057880 No Medico - Legal Department, MedAssess, Sydney, New South Wales, Australia Petar Avramovski avramovski@gmail.comom 100319475328460057881 100319475328460057881 Yes University “St Kliment Ohridski” Bitola, Clinical Hospital - Bitola, Department of Internal medicine, Bitola, North Macedonia Liljana Todorovska liljana_todorovska@yahoo.com 100319475328460057882 0009-0001-3257-8523 No Clinical Hospital - Bitola, Department of Nuclear medicine, Bitola, North Macedonia Stefan Talev stefantalev@hotmail.com 100319475328460057883 100319475328460057883 No Clinical Hospital - Bitola, Department of Surgery, Bitola, North Macedonia Svetlana Stefanovska svetlanastefanovska1973@gmail.com 100319475328460057884 0009-0004-5934-3267 No Clinical Hospital - Bitola, North Macedonia, Department of Cardiology, Bitola, North Macedonia Kosta Sotiroski kostasotiroski@gmail.com 100319475328460057885 100319475328460057885 No University Dejan Zdraveski dejan.zdraveski@uklo.edu.mk 100319475328460057886 100319475328460057886 No Faculty of Economics - Prilep, University