en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> The present study aimed to evaluate the relationship between Carotid intima-media thickening (CIMT) with subclinical myocardial ischemia in acute cardiac ischemia (ACI) patients. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This prospective, observational study was conducted on 75 ACI patients referred to Golestan and Imam Khomeini hospitals of Ahvaz in 2023. The patients in healthy (CIMT&le;0.8mm) and at risk of cardiac ischemia (CIMT>0.8mm) groups underwent carotid Doppler ultrasound to check CIMT and the presence of carotid plaque. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> CIMT mean was 1.07&plusmn;0.12 mm in healthy ACI patients and 1.4&plusmn;0.19 mm in those at risk of cardiac ischemia. Among patients at risk of CIMT and carotid plaque, 85.1% and 80.8% had at least one cardiovascular risk factor, respectively. However, no significant differences were found between CIMT, carotid plaque, and patients&#39; risk factor profiles (P = 0.129 vs. P = 0.515). The adjusted odds ratio (OR) for CIMT was 1.50 (95% CI: 0.58&ndash;3.94, P = 0.400), indicating no significant association with the outcome. No significant associations were observed for age, sex, diabetes, hypertension, LDL, or HDL. While the prevalence of vessel disease was higher in at-risk group than healthy CIMT group, no dramatic differences were observed between CIMT and vessel involvement (P = 0.136).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The presence of one or more cardiovascular risk factors combined with increased CIMT may increase heart attack susceptibility, highlighting the potential of CIMT as an effective screening tool for predicting coronary artery disease. Further large-scale studies are needed to define its role in clinical practice more definitively.</span></span></span><br> &nbsp; Myocardial Ischemia, Carotid Intima-Media Thickness, Cardiovascular Diseases, Ultrasonography, Doppler 97 105 http://caspjim.com/browse.php?a_code=A-10-3617-1&slc_lang=en&sid=1 Yasaman Zeid Shafiei yasaman.zeidshafiei@gmail.com 100319475328460055793 0009-0005-3063-9512 No Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mahsa Akhavan Sabagh mahsa.akhn@gmail.com 100319475328460055794 100319475328460055794 No Department of Radiology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Habib Haybar haybarhabib@gmail.com 100319475328460055795 100319475328460055795 Yes Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Shirin Azizidoost shirin_azizidoost@yahoo.com 100319475328460055796 100319475328460055796 No Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran