en Traditional Medicine Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Chronic tonsillitis can lead to various complications in childhood. Various treatment methods, including pharmaceutical treatments, surgery, and complementary medicine, have been used to treat it. Iranian traditional medicine has mentioned the effects of black mulberry on tonsillitis. Hence, this study aimed to investigate the effects of black mulberry syrup on tonsil hypertrophy. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This controlled clinical trial study involved 5- to 15-year-old children referred to Bu-Ali Hospital, Sari. First, 76 patients were allocated equally to the intervention or control groups using randomized blocks of four. In a three-week period, the intervention group received black mulberry syrup, whereas the control group received the placebo. Data analysis was done in SPSS Version 20, using Mann&ndash;Whitney U and McNemar tests. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The study results revealed significant differences between the intervention and control groups regarding the primary outcomes of the intervention, including the size of the tonsils, oral breathing during sleep, nocturnal snoring, and hypernasal speech (P=0.001). The intervention group showed significant improvement in these symptoms compared to the control group. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The findings of this study suggest that black mulberry syrup effectively alleviated tonsillitis symptoms in the intervention group compared to the control group. In addition, no side effects or drug complications were reported in any study participants.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; Black mulberry, Tonsillitis, Children, Traditional Persian medicine, Complementary Medicine, Medicinal Plants 731 740 http://caspjim.com/browse.php?a_code=A-10-1215-2&slc_lang=en&sid=1 Mohamadali Pourabbasi dr_pourabbasi.ma@yahoo.com 100319475328460054699 0009-0004-7733-863x No Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mehdi Nikkhah atinik1357@yahoo.com 100319475328460054700 100319475328460054700 No Department of Otorhinolaryngology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Nasser Behnampour behnampour@yahoo.com 100319475328460054701 100319475328460054701 No Department of Biostatistics and Epidemiology, School of Health, Golestan University of Medical Sciences, Gorgan, Iran. Seyde Sedighe Yousefi s.yousefi@mazums.ac.ir 100319475328460054702 100319475328460054702 Yes Department of Traditional Medicine, School of Medicine, Traditional and Complementary Medicine Research Center, Addiction Institute Mazandaran University of Medical Sciences, Sari, Iran