en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Accurate diagnosis of aortic stenosis (AS) severity is crucial for effective treatment. This study aimed to define cutoff values for aortic ejection dynamic parameters, including ejection time (ET), acceleration time (AT), and the AT/ET ratio in patients with severe AS.<span lang="FA" dir="RTL" style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> In both severe AS and control groups, the aortic valve area (AVA) was estimated using the continuity equation, and the trans-aortic mean pressure gradient (MPG) was measured using continuous-wave Doppler echocardiography. Blood flow time-velocity integral in the left ventricular outflow tract (LVOT TVI) was measured with pulsed-wave Doppler ultrasound, placing the sample volume 1 cm below the aortic valve. Severe AS was defined as AVA &le;1 cm² and MPG &ge; 40 mmHg. Clinical data were recorded, and 2D and Doppler echocardiography, including ejection dynamic parameters were analyzed.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> AT with a cutoff of 73 ms demonstrated perfect accuracy in diagnosing severe AS, with both sensitivity and specificity of 100%. ET with a cutoff of 278 ms showed 90% sensitivity and 100% specificity for identifying severe AS. Additionally, the AT/ET ratio exhibited a positive relationship with MPG (r = 0.55, P = 0.001) and a negative relationship with AVA (r = -0.52, P = 0.003). The AT/ET ratio, using a cutoff value of 0.278, yielded a sensitivity of 96% and a specificity of 100% for diagnosing severe AS.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Aortic Doppler ejection dynamic parameters can serve as complementary assessment indices, diagnosing severe AS with acceptable accuracy.</span></span></span><br> &nbsp; Cardiovascular disease, Doppler Effect, Echocardiography, Acceleration, Aortic Valve Stenosis 106 112 http://caspjim.com/browse.php?a_code=A-10-3523-1&slc_lang=en&sid=1 Mohammad Reza Aghajankhah Tamijan1234@gmail.com 100319475328460055797 100319475328460055797 No Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Mansour Abooee ma.mehrizi54@gmail.com 100319475328460055798 0009-0004-0329-1226 No Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, Guilan University of Medical Sciences, Rasht, Iran. Hassan Moladoust hmoladost@yahoo.com 100319475328460055799 100319475328460055799 No Healthy Heart Research Center, Department of Medical Physics, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran. Mohammad Assadian Rad assadianradmohammad@gmail.com 100319475328460055800 100319475328460055800 Yes Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.