en Hematology Hematology Original Article Original Article <span style="font-family:Times New Roman;"><span style="font-size:14px;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Thrombin generation (TG) assays have been developed to assess the overall coagulability of blood, as thrombin plays a pivotal role in hemostasis and thrombosis. Although increased TG has been associated with acute myocardial infarction (MI) in some previous reports, the results have been inconsistent. This study aimed to evaluate TG in platelet-poor plasma specimens from patients with confirmed acute MI.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> In this case-control study, we enrolled a total of 50 patients diagnosed with acute MI using convenience sampling, along with 50 healthy individuals. TG assays were performed in both groups, and the calculated TG indices were compared.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Forty-one patients with confirmed acute MI (24 males, 17 females; mean age 62.7&plusmn;14.9 years) and 50 healthy controls (40 males, 10 females; mean age 57.5&plusmn;12.9) were included in the analysis. TG assay indices were not significantly different in acute MI patients compared to healthy subjects (p >0.05). In terms of the diagnostic utility of TG assays, a five-variable panel yielded an AUC of 0.659 [95% CI: 0.547-0.770, P=0.010], with a sensitivity of 65.9% and specificity of 62% for identifying acute MI.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> All TG parameters taken together appear to have a predictive value in detecting acute MI. However, further studies with larger sample sizes are needed to confirm this finding.</span></span></span><br> &nbsp; Myocardial infarction, Thrombin generation, Endogenous Thrombin Potential, Atherothrombosis, Coagulation 82 89 http://caspjim.com/browse.php?a_code=A-10-3507-1&slc_lang=en&sid=1 Omidreza Zekavat ozekavat@gmail.com 100319475328460055771 100319475328460055771 No Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Shojaie shojaie1300@Yahoo.com 100319475328460055772 100319475328460055772 No Cardiology department, Research center of Non-Communicable Diseases, Jahrom University of medical sciences, Jahrom, Iran Hoda Sezavarian hodasezavarian@yahoo.com 100319475328460055773 100319475328460055773 No Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Sonia Rostami Ghorbani s_rostami_74@yahoo.com 100319475328460055774 100319475328460055774 No Cardiology department, Research center of Non-Communicable Diseases, Jahrom University of medical sciences, Jahrom, Iran Seyed Javad Dehghani javaddehghani1978@gmail.com 100319475328460055775 100319475328460055775 No Neshat Laboratory Research Center, Shiraz, Iran Javad Gerdabi javad.gerdabi@gmail.com 100319475328460055776 100319475328460055776 No Neshat Laboratory Research Center, Shiraz, Iran Peyman Izadpanah peymanizadpanah@gmail.com 100319475328460055777 100319475328460055777 No Cardiology department, Shiraz University of Medical Sciences, Shiraz, Iran Shirin Parand shirinparand47@gmail.com 100319475328460055778 100319475328460055778 No Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Sezaneh Haghpanah sezanehhaghpanah@gmail.com 100319475328460055779 100319475328460055779 Yes Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran