en Traditional Medicine Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Treatments for acute bronchitis is usually a supportive care to relieve upper respiratory symptoms. </span>This study aimed to evaluate the effect of <i>Plantago major</i> syrup (PMS) on cough severity in acute bronchitis.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> Patients (20-75 years-old) referred to the clinic of infectious diseases in Ayatollah Rouhani Hospital, Babol, Iran with a complaint of cough and the Bronchitis Severity Scale (BSS) &ge;5 entered the study. The patients randomly received PMS or placebo 30 ml/day for 10 days. Patients were visited before treatment and on days 5 and 10 after treatment. <span lang="EN">The primary outcome was BSS score and secondary outcome was </span>the life quality that was measured by means of the Persian version of the Leicester Cough Questionnaire (LCQ) at the first visit and on the 10^th day.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Of the 121 patients diagnosed with acute bronchitis, 80 eligible patients (42.87&plusmn;11.75 years-old) were randomly divided into PMS and placebo groups. The BSS score in the PMS group after 10 days was significantly lower than that of the placebo group (P=0.001). Frequency of cough (P=0.001), sputum production (P=0.005), and chest wall pain (P=0.008) were significantly lower in the PMS group than in the placebo group. In terms of quality of life, all items, including psychological, physical, and social domains, as well as total scores, were altered significantly in the PMS group compared to placebo. During monitoring of side effects, no significant adverse effects were stated in either group.&nbsp; </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">The study indicates the palliative effects of PMS in relieving the symptoms of acute bronchitis and improving quality of life</span>. </span></span></span><br> &nbsp; Persian medicine, Complementary Therapies, Cough, Herbal 651 658 http://caspjim.com/browse.php?a_code=A-10-698-6&slc_lang=en&sid=1 Alireza Naderi alirezanaderi1355@yahoo.com 100319475328460049992 100319475328460049992 No Student research center, Babol University of Medical Sciences, Babol, Iran Seyyed Ali Mozaffarpur seyyedali1357@gmail.com 100319475328460049993 100319475328460049993 Yes Traditional Medicine and History of Medical Sciences Research Center, Babol University of Medical Sciences, Babol, Iran Hoda Shirafkan hodashirafkan@gmail.com 100319475328460049994 100319475328460049994 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Masoumeh Baiany m_baiany@yahoo.com 100319475328460049995 100319475328460049995 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Zahra Memariani memarianiz@gmail.com 100319475328460049996 100319475328460049996 No Traditional Medicine and History of Medical Sciences Research Center, Babol University of Medical Sciences, Babol, Iran