Caspian Journal of Internal Medicine

en Relationship Mitral valve prolapse syndrome and duodenal ulcer disease with concomitant autonomic dysfunction Gastroentrology Gastroentrology Original Article Original Article Background: There is no evidence regarding the crucial topic of possible correlation between duodenal ulcer disease and mitral valve prolapse syndrome. We herein investigated the potential relationship between these two disorders. Methods: Eighty-three hospitalized patients with active duodenal ulcer disease were compared with 31 healthy controls for the presence of mitral valve prolapse syndrome. All participants underwent cardiac examination and echocardiography. Heart rate, systolic and diastolic pressures were estimated in supine baseline and standing positions. Results: Echocardiographic mitral valve prolapse was present in 36 (43.37%) of the patients and only in 1 (3%) of controls (P=0.001). Auscultatory findings of systolic murmurs (50% vs. 4%, respectively; P=0.001) and symptoms related to the cardiovascular system (i.e., chest pain: 75% vs. 30%, respectively; P=0.001) were more common in patients with mitral valve prolapse than those without it. Heart rate was lesser in patients with mitral valve prolapse in supine location (71.00±1.73 vs. 76.10±1.66, respectively; P=0.04), and was higher in the upright location in patients than those without mitral valve prolapse (91.54±2.73 vs. 83.42±2.71, respectively; P=0.04) and in normal controls (91.54±2.73 vs. 84.06±2.02, respectively; P=0.03). Moreover, blood group O and male gender were more common among the patients with mitral valve prolapse, compared to normal controls (67% vs. 39%, respectively; P=0.03, and 61% vs. 35%; P=0.05, respectively). Conclusion: Our findings suggest a clinical and genetic relationship between active duodenal ulcer and mitral valve prolapse syndrome connected with autonomic dysfunction. Further studies are warranted to confirm this crucial topic.   Duodenal ulcer disease, peptic ulcer, mitral valve prolapse syndrome, autonomic dysfunction, genetics 328 335 http://caspjim.com/browse.php?a_code=A-10-3228-1&slc_lang=en&sid=1 Jannis Kountouras jannis@auth.gr 100319475328460052285 100319475328460052285 Yes Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Stergios Polyzos spolyzos@auth.gr 100319475328460052286 100319475328460052286 No First Laboratory of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Macedonia, Greece Christos Zavos czavos@ymail.com 100319475328460052287 100319475328460052287 No Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Evangelos Kazakos ekazakos@gmail.com 100319475328460052288 100319475328460052288 No Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Maria Tzitiridou-Chatzopoulou mariatzitiridou@gmail.com 100319475328460052289 100319475328460052289 No Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Dimitrios Chatzopoulos gastro2010@gmail.com 100319475328460052290 100319475328460052290 No Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Aggeliki Stogianni pnikolopoulos@yahoo.com 100319475328460052291 100319475328460052291 No Department of Radiology, Ippokration Hospital, 54642 Thessaloniki, Macedonia, Greece Maria Touloumtzi toulmaria@gmail.com 100319475328460052292 100319475328460052292 No Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Stergios Arapoglou arapos1@hotmail.com 100319475328460052293 100319475328460052293 No Department of Internal Medicine, Second Medical Clinic, Ippokration Hospital, Aristotle University of Thessaloniki, 54642 Thessaloniki, Macedonia, Greece Elisabeth Vardaka evardaka@ihu.gr 100319475328460052294 100319475328460052294 No Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, Alexander Campus, Sindos 57400, Macedonia, Greece