en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.2pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Diabetes mellitus (DM) is highly consequential to global health among chronic diseases. Due to a limited researches that have examined relationships between liver enzymes and DM, this study aimed to investigate the link between elevated liver enzymes and diabetes among Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan cohort study (PGCS) population.</span><br> <span style="line-height:14.2pt"><b><i><span style="color:blue">Methods:</span></i></b> <span style="color:black">This cross-sectional study was conducted on 10519 individuals. </span><span lang="EN"><span style="color:black">The</span></span><span style="color:black"> demographic and clinical </span><span lang="EN"><span style="color:black">information of the participants was recorded. The </span></span><span style="color:black">changes in alanine aminotransferases (ALT) and aspartate aminotransferases (AST), alkaline phosphatase (ALP), and &gamma;-glutamyltransferase (GGT) were evaluated. IBM SPSS Version 21 was used to analyze the data, with a significance level < 0.05. </span></span><br> <span style="line-height:14.2pt"><b><i><span style="color:blue">Results:</span></i></b> The frequency of diabetes was 24.1% and was more prevalent in women than men (27.4% vs. 20.2%, p< 0.001). <span lang="EN">After removing all confederates, patients with elevated ALT, AST, GGT, and ALP levels were 1.27, 1.27, 1.52, and 1.46 times more likely to have diabetes, respectively. </span>The likelihood of developing diabetes rose in correlation with the number of elevated liver enzymes, up to almost 1.77-fold among subjects with three or four increased liver enzymes.</span><br> <span style="line-height:14.2pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Patients diagnosed with diabetes exhibited significantly increased levels of liver enzymes compared to those without diabetes. Also, impairment of three or four liver enzymes demonstrated a positive correlation with an elevated likelihood of DM. This indicates the importance of considering the liver status in the management of the DM population.</span></span></span><br> &nbsp; Diabetes, Liver Enzymes, Dyslipidemia, Prevalence 73 82 http://caspjim.com/browse.php?a_code=A-10-2942-3&slc_lang=en&sid=1 Mohammad Taghi Ashoobi doctorAshoobi@gmail.com 100319475328460050497 100319475328460050497 No Guilan University of Medical Sciences Farahnaz Joukar farajov@gmail.com 100319475328460050498 100319475328460050498 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Kourosh Mojtahedi K.moj2013@yahoo.com 100319475328460050499 100319475328460050499 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Saman Maroufizadeh Saman.maroufizadeh@gmail.com 100319475328460050500 100319475328460050500 No Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran. Mohammadreza Javid Mhmjavid@gmail.com 100319475328460050501 100319475328460050501 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Ali Parvaneh Alipr1334175@gmail.com 100319475328460050502 100319475328460050502 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Tahereh Zeinali tarane.zeinali@gmail.com 100319475328460050503 100319475328460050503 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Niloofar Faraji niloofarfaraji.sci@gmail.com 100319475328460050504 100319475328460050504 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Mohammadreza Naghipour naghi@gums.ac.ir 100319475328460050505 100319475328460050505 No Gastrointestinal and Liver Disease Research Center Guilan University of Medical Sciences Fariborz Mansour-Ghanaei fmansourghanaei@gmail.com 100319475328460050506 100319475328460050506 Yes Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran