Caspian Journal of Internal Medicine

en Decreased plasma levels of sestrin-1 and sestrin-2 in patients with coronary artery disease and their association with the disease severity Biochimestry Biochimestry Original Article Original Article Background: Oxidative stress has been well established to participate in the pathology of coronary artery disease (CAD). Sestrin family of proteins have recently emerged as important suppressors of oxidative stress. However, only few studies have reported the levels of sestrins and their clinical significance in CAD patients. Methods: Participants were ninety patients referred to the cardiac angiography unit for cardiac angiography. Thirty-two subjects were diagnosed as having stable CAD, twenty patients had unstable CAD and thirty-eight subjects had no CAD. All patients underwent angiography and the severity of coronary stenosis was calculated by modified Gensini score. The levels of glucose, triglyceride, total cholesterol, HDL, LDL, hs-CRP and hematological parameters were determined in the fasting blood samples by routine methods. Plasma levels of sestrin-1 and sestrin-2 were measured by ELISA. Results: Although the plasma levels of sestrin-1 were significantly lower in both case groups compared with the control group, there were no significant differences in sestrin-1 levels between the two patient groups. The levels of sestrin-2 were also significantly lower in both CAD groups than in controls, but no significant difference was found between stable and unstable patients. In the whole study subjects, plasma sestrin-1 and sestrin-2 showed negative correlation with the coronary artery score. By multivariate analysis only sestrin-2 levels were significantly related to CAD severity. Conclusion: Our findings showed a negative association of sestrin levels and the coronary stenosis severity.   Coronary artery disease, sestrins, Sesn1 protein, Sesn3 protein, coronary stenosis. 255 262 http://caspjim.com/browse.php?a_code=A-10-3219-1&slc_lang=en&sid=1 Somayeh Heidar Beygi sbeygi276@gmail.com 100319475328460052215 0009-0009-9186-2338 No Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran Gholamreza Namazi namazimajid@gmail.com 100319475328460052216 100319475328460052216 Yes Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran Parastoo Asa parastoo.asa@gmail.com 100319475328460052217 100319475328460052217 No Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran Raziyeh Salami raziyehsalami@gmail.com 100319475328460052218 100319475328460052218 No Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran Alireza Mafi armafi.m@gmail.com 100319475328460052219 100319475328460052219 No Department of Clinical Biochemistry, School of Medicine, Kashan University of Medical Sciences, Kashan. I.R. Iran Fariba Raygan rayegan.fariba@gmail.com 100319475328460052220 100319475328460052220 No Department of Cardiology, School of Medicine, Kashan University of Medical Sciences, Kashan, I.R. Iran