en Neurology Neurology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Lower urinary tract symptoms (LUTS) are common complications in patients with multiple sclerosis (MS). Different studies evaluated the effects of Onabotulinumtoxin on urinary findings in patients with MS. We designed this systematic review and meta-analysis to estimate pooled efficacy of intra-detrusor injections of botox for urinary symptoms in patients with MS.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods</span></i></b><i><span style="color:blue">:</span></i> A comprehensive systematic search was conducted on five databases of PubMed, Scopus, EMBASE, Web of Science, and Google scholar on February 2022. . We extracted data regarding the total number of participants, first author, publication year, the country of origin, mean age, F/M ratio, duration of the disease, duration of the treatment, mean Expanded Disability Status Scale&nbsp;(EDSS), maximum cystometric capacity (MCC), and maximum detrusor pressure (MDP).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results</span></i></b><i><span style="color:blue">:</span></i> Preliminary search of databases retrieved 1618 articles, after deduplication, 934 studies remained. Five studies were included for meta-analysis. The most frequent country of origin was the USA, and the mean EDSS ranged between 2.9 and 5.1. Urinary tract infection (UTI) and urinary retention were the most prevalent complications. The SMD of MDP (MDP _{week 12}-MDP _baseline) was -1.32(95%CI:-1.77, -0.37) (I²=52.9%, P=0.1). The SMD of MCC (MCC _{week 12}-MCC _baseline) was 1.65 (95%CI: 0.44, 2.86) (I²=92.4%, p<0.001). The SMD of MDP (MDP _{week 4}-MDP _baseline) was -3.6 (95%CI:-7.3, 0.16) (I²=98.3%, p<0.001). The SMD of MCC (MCC _{week 4}-MCC _baseline) was 5.05 (95%CI: 0.14, 9.96) (I²=98.8%, p<0.001).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusions:</span></i></b> This systematic review and meta-analysis demonstrated that injection of intra-detrusor Onabotulinumtoxin had a positive effect on improving urodynamic findings in patients with MS.</span></span></span><br> &nbsp; multiple sclerosis, urinary, systematic review. 588 598 http://caspjim.com/browse.php?a_code=A-10-2449-11&slc_lang=en&sid=1 Atena Soltanzadi soltana@yahoo.com 100319475328460055444 100319475328460055444 No Department of Radiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Omid Mirmosayyeb omid.mir@yahoo.com 100319475328460055445 100319475328460055445 No Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Amin Momeni Moghaddam momeni@yahoo.com 100319475328460055446 100319475328460055446 No Department of Radiology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeed Vaheb vahebs@yahoo.com 100319475328460055447 100319475328460055447 No Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Mahsa Ghajarzadeh m.ghajarzadeh@gmail.com 100319475328460055448 100319475328460055448 Yes Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran