en Anesthesiology Anesthesiology Original Article Original Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.5pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-GB">Bleeding during nose surgery is very important, because </span>it<span lang="EN-GB"> can cause a problem in the surgeon&#39;s field of view and lead to an increase in the probability of surgical complications. The aim of this study was to compare the local effects of tranexamic acid and phenylephrine on bleeding in rhinoplasty.</span></span><br> <span style="line-height:14.5pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN-GB">The present study is a double-blind clinical trial in which 98 patients who were candidates for rhinoplasty Shiraz were randomly divided into 49 groups of phenylephrine and tranexamic acid. In the first group, 1 cc of phenylephrine and in the second group, 1 cc of tranexamic acid was used locally and then the variables in the two groups were compared. The current study was approved by the Iranian Clinical Trial Registration Center with code IRCT20201205049602N1.</span><span lang="FA" dir="RTL" style="font-size:10.0pt"></span></span><br> <span style="line-height:14.5pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN-GB">The average blood pressure and heart rate in the phenylephrine group first increased and then decreased, but in the tranexamic acid group decreased from the beginning to 30 minutes. Based on the results of the test, there was a difference between the two groups in terms of the amount of bleeding, and a statistically significant relationship was observed. The average bleeding volume was lower in the phenylephrine group (p<0.0001).</span></span><br> <span style="line-height:14.5pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-GB">Results of this study showed that the amount of bleeding in the phenylephrine group was lower than that of tranexamic acid. It is recommended to use phenylephrine in rhinoplasty surgery to reduce bleeding and improve the surgeon&#39;s vision.<b> </b></span></span></span></span></div> Tranexamic acid, Phenylephrine, Rhinoplasty, Bleeding 690 696 http://caspjim.com/browse.php?a_code=A-10-3202-1&slc_lang=en&sid=1 Hooshang Akbari hooshangakbari48@yahoo.com 100319475328460050064 100319475328460050064 No Department of Anesthesiology and Operating Room, Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Bouali sina Hospital, Sari, Iran Ebrahim Nasiri Formi rezanf2002@yahoo.com 100319475328460050065 100319475328460050065 No Department of Anesthesiology, Operating Room and Emergencies, School of Allied Medical Sciences, Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran Abbas Alipour alipour.abbas59@gmail.com 100319475328460050066 100319475328460050066 No Department of Community Medicine, School of Medicine, Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran Hamed Delam hameddelam8@yahoo.com 100319475328460050067 100319475328460050067 No Student Research Committee, Larestan University of Medical Sciences, Larestan, Iran Esmaeil Kavi Kavi.esmaeil@gmail.com 100319475328460050068 100319475328460050068 No Department of operation room/ Anesthesia, School of Nursing, Larestan University of Medical Sciences, Lar, Iran Negar Shahkarami Negar.shahkarami@yahoo.com 100319475328460050069 100319475328460050069 Yes Faculty of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran