en Dermathology Dermathology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Acne vulgaris is a chronic, inflammatory disease and one of the most common skin diseases. Isotretinoin is the best treatment for severe nodulocystic acne compared to other systemic medicine. Although serum lipids elevation is one of the side effects of this medicine; recent studies have shown controversial results. This study aimed to assess the serum lipid profile in adolescents and adults with acne vulgaris receiving isotretinoin.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This is a cross-sectional study on 65 adolescents and adults older than 16 years old (55 females and 10 males) with moderate to severe degrees of acne vulgaris under a fixed low dose of 20 mg/day Isotretinoin treatment for 120 days.<b> </b>We analyzed the data using the SPSS software Version 16 using paired sample t-test, Wilcoxon, and ANCOVA test.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> In this study, 65 records of patients with a mean age of 22.21&plusmn;6.25 years were assessed. There was a significant elevation in Cholesterol and LDL levels, but in HDL and triglyceride levels no significant change occurred. A significant change in cholesterol levels was noticed in the adolescent age group, the female sex, and the normal weight group. Triglyceride had a significant change in the female sex and normal weight group and HDL significantly increased in male patients.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Although a low dose of isotretinoin can be used with minimal concern for changes in lipid profile in acne vulgaris patients, in the long-term follow-up and treatment, it seems that we have to administer it cautiously. </span></span></span><br> <br> <span style="font-size:11pt"><span style="line-height:normal"><span calibri="" style="font-family:"><span style="font-size:13.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span> Acne vulgaris, body mass index, Isotretinoin, lipids 659 665 http://caspjim.com/browse.php?a_code=A-10-2774-2&slc_lang=en&sid=1 Kaveh Gharaei Nejad gharaeek36@gmail.com 100319475328460049997 100319475328460049997 No Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Abbas Darjani dr.abbasdarjani@yahoo.com 100319475328460049998 100319475328460049998 No Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Narges Alizadeh narges.alizadeh7@gmail.com 100319475328460049999 100319475328460049999 No Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Seyede Tahoura Hakemzadeh tahourahkz@gmail.com 100319475328460050000 100319475328460050000 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Afagh Hassanzadeh Rad afaghrad@gums.ac.ir 100319475328460050001 100319475328460050001 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran. Ehsan Kazemnejad-Leili kazem_eh@yahoo.com 100319475328460050002 100319475328460050002 No Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.. Reyhaneh Ghadarjani ReyhanehGhadarjani@gmail.com 100319475328460050003 100319475328460050003 No Department of Pathology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Hojat Eftekhari dr.he.derm@gmail.com 100319475328460050004 100319475328460050004 No Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Rana Rafiei Rafieirana@yahoo.com 100319475328460050005 100319475328460050005 No Skin Research Center, Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Setila Dalili setiladalili1346@yahoo.com 100319475328460050006 100319475328460050006 Yes Pediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.