en Hematology Hematology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.5pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Hepatitis A is a widespread viral infection with significant public health implications. Assessing glucose 6-phosphate dehydrogenase (G6PD) deficiency in hepatitis A patients is essential for various reasons, including prognosis, disease severity evaluation, encephalopathy risk identification, tailored management, and advancing scientific understanding. This study aimed to investigate the prevalence and clinical implications of G6PD impairment in individuals with fulminant hepatitis A.</span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Methods:</span></i></b> A cross-sectional descriptive analysis was conducted, involving hospitalized patients with fulminant hepatitis A. Demographic data, prevalence rates, and clinical findings were recorded in a database. The diagnosis of hepatitis A infection was confirmed using an anti-HAV IgM antibody test, and G6PD enzyme activity was measured with a fluorescent spot assay.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Results:</span></i></b> Out of 81 patients with hepatitis A, 57 (70.4%) were males, and 24 (29.5%) were females, with an average age of 24.6 years. Dark yellow urine and anorexia were the most common clinical symptoms. Notably, 30 (37%) patients lacked G6PD. The group with G6PD deficiency showed significantly higher rates of encephalopathy and mortality (P<0.01), along with elevated bilirubin (P=0.00), abnormal coagulation parameters, and low hemoglobin levels (P=0.00).<b> </b><b><span style="font-size:10.0pt"></span></b></span><br> <span style="line-height:13.5pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> In light of these findings, the present study proposes the implementation of routine G6PD level assessments and the evaluation of other relevant markers in regions where hepatitis A is endemic. Furthermore, the study underscores the need for vigilant monitoring of hemolysis and encephalopathy in affected patients to optimize clinical management and reduce morbidity and mortality associated with this condition.<span style="font-size:10.0pt"></span></span></span></span><br> &nbsp; G6PD Deficiency, Hepatitis A, fulminant hepatitis 451 458 http://caspjim.com/browse.php?a_code=A-10-3127-1&slc_lang=en&sid=1 Fardad Ejtehadi ma.sood.tahani@gmail.com 100319475328460048944 100319475328460048944 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Maryam Sadat Serpoosh mas.ood.tahani@gmail.com 100319475328460048945 100319475328460048945 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Iraj Shahramian m.asood.tahani@gmail.com 100319475328460048946 100319475328460048946 Yes Department of Pediatrics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Ladan Aminlari maso.od.tahani@gmail.com 100319475328460048947 100319475328460048947 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Ramin Niknam masoo.d.tahani@gmail.com 100319475328460048948 100319475328460048948 No Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Gholam Reza Sivandzadeh masood.ta.hani@gmaail.com 100319475328460048949 100319475328460048949 No Gastroenterohepatology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Masoud Tahani masood.tahani@gmail.com 100319475328460048950 100319475328460048950 No Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran Amin Javadifar masood.tah.ani@gmail.com 100319475328460048951 100319475328460048951 No Immunology Research Center, Inflammation and Inflammatory Diseases Division, Mashhad University of medical sciences, Mashhad, Iran Fateme Sharafi masood.taha.ni@gmail.com 100319475328460048952 100319475328460048952 No Pediatric Gastroenterology and Hepatology Research Center, Zabol University of Medical Sciences, Zabol, Iran Maryam Moini 100319475328460048953 100319475328460048953 No Division of Gastroenterology, University of Ottawa, Ottawa, Canada