en Oncology Oncology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14.3pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">: </span></i>Drugs used in chemotherapy specifically target and kill the cancer cells during the breast cancer treatment. However, the majority of anti-cancer therapies are non-specific, which will harm the innate cells. Our research work assessed the impact of chemotherapy with adriamycin/cytoxan (AC) on the influence of antioxidant enzymes and hematopathological profiles in the diagnosis and prognosis of breast cancer treated with chemotherapy.</span><br> <span style="line-height:14.3pt"><b><i><span style="color:blue">Methods: </span></i></b>40 breast cancer patients treated with AC chemotherapy (Adriamycin 60 mg/m2, Cytoxan 600 mg/m2) between July 2020 and March 2021 are part of this prospective study. The first sample was taken prior to chemotherapy, the second after the intervention&#39;s three cycles, and the third after the intervention&#39;s last cycle. Spectrophotometric technique was used to evaluate the amounts of antioxidant enzymes in serum samples. Patients&rsquo; demographic variables, clinical features, biochemical andhematogical parameters data were noted. The data was compared before and after treatment using the Paired-t test.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14.3pt"><b><i><span style="color:blue">Results:</span></i></b>55% of the patients were detected with carcinoma on left breast and majority was in Grade 3 clinical stage 37.5%. Most of the patients express estrogen and progesterone receptors 72.5%. Our findings demonstrated that a significant decrease in the mean values of antioxidant enzymes MDA, NO, TAS, CAT, GPx, GR, SOD and GST along with hematological parameters after three cycles of AC treatment in breast carcinoma <span style="color:black">individuals.<b> </b>The p-value is < 0.05. </span><span style="color:red"></span></span><br> <span style="line-height:14.3pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">: </span></i>Our research demonstrates that the body&#39;s oxidant/antioxidant system, particularly reduction levels and antioxidant enzyme activity, is drastically altered by AC chemotherapy in breast carcinoma individuals.<span style="font-size:10.0pt"></span></span></span></span> Breast carcinoma, Antioxidants, AC chemotherapy, Haematological parameters 132 140 http://caspjim.com/browse.php?a_code=A-10-3117-1&slc_lang=en&sid=1 Tejaswi Pullakanam micropub.gimsr@gmail.com 100319475328460050544 100319475328460050544 Yes Department of Biochemistry, Aarupadai, Veedu Medical College & Hospital, Vinayaka Mission‘s Research foundation (VMRF-DU), Pondicherry, Tamilnadu, India Murugan Mannangatti drmurugan@vinayakamissions.com 100319475328460050545 100319475328460050545 No Professor Alamuri Ramesh alamuriramesh@gmail.com 100319475328460050546 0009-0008-2217-2045 No Assistant Professor Pradeep Kumar B pradeepsankalp1@gmail.com 100319475328460050547 0004-0008-4830-4675 No Research scholar Ramakrishna Nekkala grpbiochem123@gmail.com 100319475328460050548 100319475328460050548 No Professor Payala Vijayalakshmi vpayala@gitam.edu 100319475328460050549 0009-0001-1727-1961 No Associate Professor