en Neurology Neurology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Cognitive impairment (CI) is one of the main features of multiple sclerosis (MS). Cognitive rehabilitation (CR) programs are crucial for improving cognition and computer-assisted cognitive rehabilitation is considered as an effective method for cognition rehabilitation. To assess the effects of computer-based cognitive rehabilitation program on cognition in patients with multiple sclerosis (MS).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods</span></i></b><i><span style="color:blue">:</span></i> We performed a comprehensive search in PubMed, Scopus, Web of Science, EMBASE, and Google Scholar databases along with gray literature up to September 2021. Randomized clinical trials, articles had been published in the English language. We evaluated the risk of potential bias via the Cochrane Collaboration&#39;s tool for assessing the risk of bias. Standardized mean difference (SMD) was calculated.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results</span></i></b><i><span style="color:blue">:</span></i> The preliminary search retrieved 2302 articles by literature search, after deleting duplicates 2248 remained.&nbsp; Eight articles remained for meta-analysis. Totally, 235 patients in intervention group and 192 in control group were evaluated. Mean age ranged from 43.5-52 years. The SMD of PASAT (Paced Auditory Serial Addition Test) (Case-control) test was 0.35 (95%CI:0.1-0.66) (I2:24.4%, P=0.2). The SMD of SDMT (Case-control) test was 0.07 (95%CI:-0.18-0.33). The SMD of PASAT before and after intervention in case group was 0.68 (95%CI:0.45-0.91) (I2:40%, P=0.15). The SMD of SDMT before and after intervention in case group was 0.44 (95%CI:0.21-0.66) (I2:40%, P=0.15).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusions:</span></i></b> The results of this systematic and meta-analysis showed that computerized cognitive rehabilitation program is effective in improving PASAT score.</span></span></span><br> &nbsp; <h3 style="margin-top:18px; margin-bottom:3px"><span style="font-size:13.5pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:15.0pt"><span style="background:yellow"><span style="font-weight:normal"><a href="https://www.nationalmssociety.org/For-Professionals/Researchers/Resources-for-MS-Researchers/Research-Tools/Clinical-Study-Measures/Paced-Auditory-Serial-Addition-Test-(PASAT)" style="color:#0563c1; text-decoration:underline"><span style="text-decoration:none"><span style="text-underline:none"></span></span></a></span></span></span></span></span></h3> Multiple sclerosis, cognition, rehabilitation. 9 19 http://caspjim.com/browse.php?a_code=A-10-2449-8&slc_lang=en&sid=1 Abdorreza Naser Moghadasi abdorrezanasermoghadasi@gmail.com 100319475328460050455 100319475328460050455 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Omid Mirmosayyeb omid.mirmosayeb@gmail.com 100319475328460050456 100319475328460050456 No Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Sara Bagherieh bagheriehs@gmail.com 100319475328460050457 100319475328460050457 No Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Mohammad ali Sahraian sahraian1351@yahoo.com 100319475328460050458 100319475328460050458 No Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Mahsa Ghajarzadeh mghajar2@jhmi.edu 100319475328460050459 100319475328460050459 Yes Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran