en pharmacology pharmacology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Opioid dependence, is one of the world&#39;s most critical health problems. Deaddicta is a herbal product considered an effective treatment for opioid addiction. Deaddicta&#39;s efficacy in the maintenance treatment of patients with opioid use disorder has recently been demonstrated through a double-blind randomized controlled trial (RCT). This study aimed to evaluate the permanence of Deaddicta&#39;s efficacy six months after the end of the maintenance treatment for opioid dependence.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This study was performed following the previous RCT on the maintenance treatment of opioid addicts. Out of 41 participants who completed the study for three months in the previous research, 15 from the intervention group (Deaddicta capsules, 1500 mg/day) returned for follow-up. They all previously fulfilled the DSM-IV criteria for addiction, were aged 18 to 65, and had discontinued Deaddicta for six months. The outcome measures included addiction severity, depression and anxiety levels, and craving score. The scores of each parameter were compared in three phases:&nbsp; before intervention; after three months of intervention; and six months after the end of the study.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Depression, anxiety, and craving scores decreased six months after the end of the previous study. This decrease was significant in the craving score (<i>P</i> = 0.011). No significant increase was observed in the frequency of use. The regression analysis showed a negative relationship between craving and the progression of phases.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> The Deaddicta product may have desirable and effective properties in decreasing temptation and, as a result, the maintenance treatment of opioid dependence.</span></span></span><br> &nbsp; Craving, Datura Stramonium L, Opium dependence, Persian Medicine. 318 327 http://caspjim.com/browse.php?a_code=A-10-2963-2&slc_lang=en&sid=1 Abdolali Moosavyzadeh alimoosavy@yahoo.com 100319475328460047771 100319475328460047771 No Department of Persian Medicine, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran Farzaneh Ghaffari f_ghaffari@sbmu.ac.ir 100319475328460047772 100319475328460047772 No School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Bagher Mohammad Bagher Saberi zafarghandi saberiza4@yahoo.com 100319475328460047773 100319475328460047773 No Department of Addiction, School of Behavioral Sciences and Mental Health, Tehran Institute of Psychiatry, Iran University of Medical Sciences, Tehran, Iran. Majid Talafi Noghani m.noghani@shahed.ac.ir 100319475328460047774 100319475328460047774 No Department of Traditional Medicine, School of Persian Medicine, Shahed University, Tehran, Iran. Hossein Hassanpour hassanpour-h@vet.sku.ac.ir 100319475328460047775 100319475328460047775 No Department of Basic Sciences, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran Fatemeh Emadi fatemeh12emadi@yahoo.com 100319475328460047776 100319475328460047776 No Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran Fatemeh Alijaniha falijaniha@yahoo.com 100319475328460047777 100319475328460047777 No Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran Zahra Bahaeddin z.bahaedin@gmail.com 100319475328460047778 100319475328460047778 No Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran Leila Nasiri leilanasiri1988@gmail.com 100319475328460047779 100319475328460047779 No Department of Health Equity, Immunoregulation Research Center, Shahed University, Tehran, Iran Razieh Jafari Hajati r.jafari.hajati@gmail.com 100319475328460047780 100319475328460047780 No Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran Mohsen Naseri naseri@shahed.ac.ir 100319475328460047781 100319475328460047781 Yes Traditional Medicine Clinical Trial Research Center, Shahed University, Tehran, Iran