en Infectious Diseases Infectious Diseases case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> Salmonella osteoarticular involvement is a rare complication, occurring in about&nbsp;2% of the cases. Septic arthritis is exceedingly rare, involving only 0.2 % of all salmonellosis patients. Endocarditis is another complication that occurs in less than 0.8 % of cases. These complications are more likely to happen among immunocompromised patients. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b> We report a previously healthy 25-year-old man who presented with left limb pain. He had been treated for brucellosis ten days earlier by his primary care physician. Arthrocentesis and subsequent hip-joint biopsy confirmed septic arthritis due to Salmonella. However, he was unresponsive to the treatment. We found no underlying immunosuppression. A trans-esophageal echo was performed due to the continued fever and positive blood cultures. It revealed Salmonella endocarditis of the na&iuml;ve tricuspid valve. He was treated via arthrotomy and antimicrobials for four weeks. Follow-up after 20 months showed no underlying immunosuppression.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b>This case highlights that in patients with positive Salmonella blood cultures and a focus of infection compatible with Salmonellosis but unresponsive to treatment, searching for other foci of infection is necessary. Furthermore, physicians in endemic areas of brucellosis should consider other differential diagnoses in patients with fever and limping because any delay in diagnosing Salmonella septic arthritis can destroy the joint space with lifelong discomfort.</span></span></span><br> &nbsp; salmonella, septic arthritis, infective endocarditis, tricuspid valve 542 545 http://caspjim.com/browse.php?a_code=A-10-2708-1&slc_lang=en&sid=1 Mahnaz Arian Arianm@mums.ac.ir 100319475328460049066 100319475328460049066 No Department of Infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Farideh Najm Sarvari farideh_najm@yahoo.com 100319475328460049067 100319475328460049067 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Moein Mohebbi mdmoein.mb@gmail.com 100319475328460049068 100319475328460049068 No Department of Infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Marzieh Kazerani kazerani1617@mshdiau.ac.ir 100319475328460049069 100319475328460049069 Yes Department of Infectious Diseases, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran