en Internal Internal Short Communication Short Communication <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Metabolic syndrome is a critical health concern associated with an elevated risk of chronic health problems including cardiovascular disease and diabetes. There are shreds of evidence that novel inflammatory ratios including neutrophil-to-lymphocyte, platelet-to-lymphocyte and lymphocyte-to-monocyte ratios serve as prognostic biomarkers for metabolic syndrome (MetS). This hypothesis was investigated in a cohort of the Iranian population.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> selection of MetS + subjects was based on the National Cholesterol Education Program Adult Treatment Panel III criteria 3 (NCEP ATP 3). The control group consisted of participants negative for any of the five MetS criteria. Demographic and laboratory data were extracted from the Tabari cohort study. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> A total of 1930 subjects including 965 Mets positive and 965 MetS criteria negative participants were evaluated. Diabetes (84.8%), hypertension (48.9%), hypertriglyceridemia (81.7%), low HDL cholesterol (70.3%), and high waist circumference (78.9%) were observed in patients. There were no differences between NLR (1.66&plusmn;0.71 vs. 1.69&plusmn;0.72 P=0.42), LMR (11.23&plusmn;3.13 vs. 11.30&plusmn;11.99, P= 0.86) and PLR (113.85&plusmn;68.67 vs 114.11&plusmn;35.85, P=0.91) between case and control groups, respectively. Logistic regression analysis revealed no association between ratios and MetS risk even after adjusting for potential confounders including age, gender, living place, and BMI.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> In a relatively large population from Northern Iran, no association was observed between CBC-derived inflammatory ratios and the presence of MetS.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Metabolic Syndrome, Neutrophil-to-lymphocyte ratio, Platelet-to-lymphocyte ratio, lymphocyte-to-monocyte ratio, Iran 567 571 http://caspjim.com/browse.php?a_code=A-10-672-3&slc_lang=en&sid=1 Versa Omrani-Nava versa.peace@gmail.com 100319475328460043085 100319475328460043085 No Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Mahmood Moosazadeh mmoosazadeh1351@gmail.com 100319475328460043086 100319475328460043086 No Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Adeleh Bahar doctor_bahar2000@yahoo.com 100319475328460043087 100319475328460043087 No Diabetes Research Center, Mazandaran University of Medical Sciences, Sari, Iran Akbar Hedayatizadeh-Omran akbar_hedayati@yahoo.com 100319475328460043088 100319475328460043088 No Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Abdolrahim Ahmadi nima.ahmadi53@gmail.com 100319475328460043089 100319475328460043089 No Gastrointestinal Cancer Research Center, Non-communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran Reza Alizadeh-Navaei reza_nava@gmail.com 100319475328460043090 100319475328460043090 Yes Gastrointestinal Cancer Research Center, Non-Communicable Diseases Institute, Mazandaran University of Medical Science, Sari, Iran