en Infectious Diseases Infectious Diseases Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span style="color:black">The present study aimed to investigate the one-year prevalence of SARS-CoV-2, common comorbidities and demographic information among negative- and positive rRT-PCR in health care workers (HCW), hospitalized and outpatients. Also, the association between SARS-CoV-2 cycle threshold (Ct) and the outcomes of patients were analyzed in Babol, northern Iran.</span><span style="color:black"></span></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Methods:</span></i></b> <span style="color:black">This large&nbsp;retrospective cross-sectional study was performed between March 2020 and March 2021. The records of 19232 hospitalized, outpatients and HCW suspected to COVID-19 were collected from teaching hospitals in the North of Iran.</span></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Results:</span></i></b><b> </b><span style="color:black">Out of the 19232 suspected to COVID-19 patients, 7251 (37.7%) had a positive rRT-PCR result; 652 (9%), 4599 (63.4%) and 2000 (27.6%) of those were categorized as HCW, hospitalized and outpatients, respectively. Moreover, between the hospitalized and the outpatient group, 10.2 and 0.8% cases died, whereas no death cases were reported in the HCW. Furthermore, it seems that death rate was significantly different between the three groups of Ct value, the highest mortality in those with Ct between 21 and 30 (group B=7.6%) and the lowest in the group with the highest Ct (between 31 and 40 = 5.5%) (<i>p</i><0.001).</span><span style="color:black"></span></span></span><br> <span style="line-height:14pt"><span new="" roman="" times=""><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b><span style="color:black">In summary, 37.7% of cases were positive for SARS-CoV-2; of which, 63.4, 27.6 and 9% were hospitalized, outpatients and HCW, respectively. With regard to the mortality rate in hospitalized patients and the significant association with Ct under 20 and 30, it seems that the early detection and the initial quantification of SARS-CoV-2 in the first week of the conflict and therapeutic considerations to reduce the relative load can reduce the mortality rate.</span></span></span></span></span><span style="font-size:12pt"><span style="line-height:14pt"><span new="" roman="" style="font-family:" times=""><span style="font-size:10.0pt"><span style="color:black"></span></span></span></span></span> COVID-19, hospitalized, health care worker, outpatient, cycle threshold (Ct) 244 253 http://caspjim.com/browse.php?a_code=A-10-137-3&slc_lang=en&sid=1 Mehrdad Halaji mehrdad.md69@gmail.com 100319475328460035627 100319475328460035627 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Abazar Pournajaf abazar_pournajaf@yahoo.com 100319475328460035628 100319475328460035628 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Farzin Sadeghi sadeghifarzin6@gmail.com 100319475328460035629 100319475328460035629 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Ali Hasanzadeh ali72hassanzadeh@gmail.com 100319475328460035630 100319475328460035630 No Mohammad Chehrazi mohamadchehrazi@gmail.com 100319475328460035631 100319475328460035631 No Hemmat Gholinia h_gholinia@yahoo.com 100319475328460035632 100319475328460035632 No Fatemeh Hejazi Amiri fafa.amiri1368@gmail.com 100319475328460035633 100319475328460035633 No Saghar Saber Amoli sagharsaberamoli2@gmail.com 100319475328460035634 100319475328460035634 No Mostafa Javanian mjavanian@gmail.com 100319475328460035635 100319475328460035635 No Masoumeh Bayani m_baiany@yahoo.com 100319475328460035636 100319475328460035636 No Mahmoud Sadeghi Haddad Zavareh drm_sadeghihz@yahoo.com 100319475328460035637 100319475328460035637 No Mehran Shokri mh.shokri90@gmail.com 100319475328460035638 100319475328460035638 No Arefeh Babazadeh drbabazadeh.a@yahoo.com 100319475328460035639 100319475328460035639 No Mana Bazi Broun manabazeboron@gmali.com 100319475328460035640 100319475328460035640 No Mohsen Mohammadi dr.mohamadi61@yahoo.com 100319475328460035641 100319475328460035641 No Hamed Mehdinezhad hamed.mng@gmail.com 100319475328460035642 100319475328460035642 No Mahmoud Monadi dr.monadi@yahoo.com 100319475328460035643 100319475328460035643 No Parviz Amri Maleh pamrimaleh@yahoo.com 100319475328460035644 100319475328460035644 No Hamid Reza Nouri h.noori@mubabol.ac.ir 100319475328460035645 100319475328460035645 No Abdolreza Daraei rezagene@gmail.com 100319475328460035646 100319475328460035646 No Mahdie Yousefnia Pasha mahdieyousefnia@yahoo.com 100319475328460035647 100319475328460035647 No Mehdi Tourani Touranimehdi4@gmail.com 100319475328460035648 100319475328460035648 No Seyed Raheleh Ahmadian rsahmadian16@gmail.com 100319475328460035649 100319475328460035649 No Nadia Esmailzadeh nadiaesmailzadeh.dice@gmail.com 100319475328460035650 100319475328460035650 No Seyyedeh Maedeh Mirtabar Maedeh_mirtabar@yahoo.com 100319475328460035651 100319475328460035651 No Shakiba Asadi shakibaasadi1991@gmail.com 100319475328460035652 100319475328460035652 No Behnaz Yousefghahary behnaz_ghahari@yahoo.com 100319475328460035653 100319475328460035653 No Mansour Babaei babaeim47@yahoo.com 100319475328460035654 100319475328460035654 No Majid Nabipour Majidnabipour@yahoo.com 100319475328460035655 100319475328460035655 No .... ..... 100319475328460035656 100319475328460035656 No Yousef Yahyapour uyahyapoor@yahoo.com 100319475328460035657 100319475328460035657 Yes Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran