en Hematology Hematology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b> <span lang="EN-MY">Cancer-related anaemia is one of the main burdens in oncology, although the available data on its prevalence and treatment options such as blood transfusion are often contradictory. This study aimed to evaluate the prevalence of anaemia and the requirement for packed red blood cell (PRBC) transfusion among women with breast cancer (BC) and to determine the associated factors for chemotherapy-induced anaemia (CIA)</span>.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN-MY">This cross-sectional retrospective study conducted in Kelantan involved 104 newly diagnosed female BC patients from 2015 to 2016 who underwent chemotherapy. For statistical analysis, chi-square was used to compare between CIA and non-CIA groups. In addition, simple and multiple logistic regression were used to determine the association of the CIA</span>.<span style="font-size:10.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN-MY">Our study revealed that 34.6% (n=36) of patients had mild anaemia, and 59.6% (n=62) had normal haemoglobin at pre-chemotherapy. The prevalence of anaemia increased from 40.4% to 77% at the end of our study. About 30.8% of patients received PRBC transfusion during chemotherapy with mean haemoglobin before the first transfusion of 7.9 g/dl. CIA was observed in 54.8% of cases. There was no significant association between CIA concerning the patient characteristic, cancer characteristic, or cancer treatment</span>.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b><b> </b><span lang="EN-MY">We concluded that a significant proportion (40.4%) of BC patients was anaemic even before chemotherapy, with the red blood cell requirements up to 30.8% throughout chemotherapy. A larger prospective study is needed to determine the predictors for the CIA and subsequently improve patient management</span>.<b><i><span style="color:#0033cc"></span></i></b></span></span></span> breast cancer, anaemia, red cell transfusion, chemotherapy 237 248 http://caspjim.com/browse.php?a_code=A-10-2578-1&slc_lang=en&sid=1 Nur Aklina Ramli aklinanur2411@yahoo.com 100319475328460041847 100319475328460041847 No Department of Clinical Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia Salfarina Iberahim Sal Salfarina salfarina78@gmail.com 100319475328460041848 100319475328460041848 No Department of Haematology and Transfusion Medicine Unit, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 15200 Kubang Kerian, Kelantan, Malaysia Hasmah Hussin hasmah.hussin@usm.my 100319475328460041849 100319475328460041849 Yes Department of Clinical Medicine, Advanced Medical and Dental Institute, Universiti Sains Malaysia, 13200 Kepala Batas, Penang, Malaysia Ahmad Arif Che Ismail scania96@gmail.com 100319475328460041850 100319475328460041850 No Blood Bank Unit, Hospital Raja Perempuan Zainab (II), 15586 Kota Bharu, Kelantan, Malaysia