en psychiatry psychiatry Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Infectious agents are considered as a possible cause of schizophrenia. The aim of this study was to evaluate the serum levels of cytomegalovirus (CMV), Toxoplasma gondii and Brucella antibodies in schizophrenia patients compared with the control group.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study was performed on 75 patients with schizophrenia who were clinically diagnosed with schizophrenia using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by two independent psychiatrists. As the controls, 75 sex and age-matched individuals were selected from orthopedic and surgical wards, who were admitted because of trauma. Anti-Toxoplasma gondii IgG antibody was detected by Abbott&#39;s company diagnostic kit. To detect anti-Brucella IgG antibodies, the enzyme-linked immunosorbent assay (ELISA) test with Vircell diagnostic kit was used. Quantitative luminescence (CLIA) method using Abbott diagnostic kit was also used to detect anti-cytomegalovirus IgG antibody (CMV IgG avidity)<span lang="EN">. </span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> There was not any clinically significant differences in the mean value of Toxoplasma, CMV and Brucella IgG antibodies between schizophrenia and control group. However, considering cut-off point for these tests and further analysis with non-parametric tests showed clinically significant difference between two groups at cut-off point 1.1 for anti-Brucella IgG antibody which indicated more positive samples in schizophrenia group (24 out of 75) than control group (12 out of 75) with a p-value less than 0.05 (0.046)<span lang="EN">.</span><b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> The results of the present study showed no association between toxoplasmosis infection and CMV and schizophrenia. However, there might be a positive correlation between anti-Brucella IgG antibody and schizophrenia.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Schizophrenia, Serology, Cytomegalovirus, Brucellosis, Toxoplasmosis 560 566 http://caspjim.com/browse.php?a_code=A-10-2614-1&slc_lang=en&sid=1 Seyed Shahab Banihashem shb_banihashem@yahoo.com 100319475328460043077 100319475328460043077 No Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran Forough Yousefi Saber yousefiforough2@gmail.com 100319475328460043078 100319475328460043078 No Department of Psychiatry, Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Somayeh Motazedian somayehmotazedian@yahoo.com 100319475328460043079 100319475328460043079 No Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran Masoud Mardani mmardani@sbmu.ac.ir 100319475328460043080 100319475328460043080 No Infectious Disease and Tropical Medicine Department, Faculty of Medicine of Shaheed Beheshti University of Medical Sciences and Health Services, Tehran, Iran Alireza Shamsi ar.shamsi@sbmu.ac.ir 100319475328460043081 100319475328460043081 No Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran Maryam Nazari maryamnazari79@gmail.com 100319475328460043082 100319475328460043082 No Department of Neurology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Nastaran Samani nastaransamani1990@yahoo.com 100319475328460043083 100319475328460043083 No Department of Psychiatry, Taleghani Hospital, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Arash Danesh arashdanesh1982@yahoo.com 100319475328460043084 100319475328460043084 Yes Department of psychosomatic medicine, Taleghani Hospital Research Development Committee, Shahid Beheshti University of medical sciences, Tehran, Iran