en Neurology Neurology Case Series Case Series <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Trigeminal neuralgia is one of the most disabling facial pain syndromes. In recent years&#39; new therapeutic strategy, incobotulinumtoxin A has emerged. The aim of the current study was to determine the time and duration of pain in 3 cases with pharmacological treatment and incobotulinumtoxin A.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case presentation: </span></i></b>In three patients with different onsets, trigeminal neuralgia was diagnosed. Pain severity was assessed by the visual analogue scale. Patient demographics and clinical data were filled in a checklist. They were females with age ranging from 39 to 49 years. Two patients had normal MRI and one patient had no any recent MRI. One center and specialist injection Xeomin 50 units for one time. Despite long time oral treatment, their symptoms had no significant improvement, but after incobotulinumtoxin A injection, pain frequency, severity and duration decreased in patients<b><i><span style="color:blue">.</span><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Result showed that the frequency, severity and duration of pain attacks was efficiently decreased by incobotulinumtoxin A with low side-effects. Its complication and side-effect should be considered in the future.<b><i><span style="color:#0033cc"></span></i></b></span></span></span> Trigeminal, Neuralgia, Pain, Iran. 376 379 http://caspjim.com/browse.php?a_code=A-10-1466-9&slc_lang=en&sid=1 Meghdad Hosseini mubmeghdad271@gmail.com 100319475328460041903 100319475328460041903 No Department of Neurology, Shahid Beheshti University of Medical Science, Tehran, Iran Farhad Asarzadegan alijanpour.sh@live.com 100319475328460041904 100319475328460041904 Yes Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Erfan Shafiee alijanpour.sh@live.com 100319475328460041905 100319475328460041905 No Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shayan Alijanpour sh.alijanpour@mubabol.ac.ir 100319475328460041906 100319475328460041906 No Student Research Committee, Faculty of Nursing and midwifery, Tehran University of Medical Science, Tehran, Iran