en Endocrinology Endocrinology Short Communication Short Communication <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Anti-TPO antibodies are one of the characteristic factors in autoimmune thyroiditis (AIT). Previous studies reported a high prevalence of anti-TPO antibodies (Abs) in Iran. We have therefore assessed the prevalence of anti-TPO Abs in Gorgan, Iran. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study, conducted from 2015 to 2018 in Gorgan city, Northeast of Iran. The Participants included women with Poly cystic ovary syndrome (PCOs), celiac patients, men with hepatitis C infection, and age and sex-matched controls. ELISA method was used for the analysis of laboratory tests.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The number of enrolled subjects in PCOs, celiac disease, and Hepatitis C infection groups were 76, 67, and 60, respectively. Anti-TPO Abs positivity was significantly higher in patients with PCOS than in the control group (18.4% vs. 0.00%; p = 0.000). There were no significant differences in the frequency of anti-TPO Abs positive cases between CD patients and the controls (26.9% vs. 21.1% p =0.413). The incidence of anti-TPO Abs positivity was significantly higher in the control group (10% vs. 25%; P = 0.031)<span lang="EN">.</span><b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> Very high level of anti-TPO Abs was observed in both patients and healthy population in Golestan province. Considering this rate and its association with autoimmune disorders, it is suggested to prioritize screening programs for related disease in this area.<b><i><span style="color:#0033cc"></span></i></b></span></span></span><br> &nbsp; Anti-thyroid Peroxidase (anti-TPO), Autoimmune thyroiditis (AIT), Celiac disease, Hepatitis C infection, Iran 371 375 http://caspjim.com/browse.php?a_code=A-10-1975-3&slc_lang=en&sid=1 Hadise Heidarpour Heidarpour.hadise@gmail.com 100319475328460041896 100319475328460041896 No Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Farnaz Hooshmand Farnaz.hooshmand.1377@gmail.com 100319475328460041897 100319475328460041897 Yes Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Fazel Isapanah Amlashi Fazelamlashi@gmail.com 100319475328460041898 100319475328460041898 No Golestan Research Center of Gastroentrology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran / Neuroscience Research Centre, Golestan University of Medical Sciences, Gorgan, Iran Behnaz Khodabakhshi 100319475328460041899 100319475328460041899 No Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran Mahsa Mahmoudi 100319475328460041900 100319475328460041900 No Student Research Committee, Golestan University of Medical Sciences, Gorgan, Iran Taghi Amiriani Dr_amiriani@yahoo.com 100319475328460041901 100319475328460041901 No Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran Sima Besharat s.besharat.gp@yahoo.com 100319475328460041902 100319475328460041902 No Golestan Research Center of Gastroenterology and Hepatology, Golestan University of Medical Sciences, Gorgan, Iran