en Hematology Hematology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Sickle cell disease (SCD) is associated with an under-recognized and well-known complication of bone marrow necrosis known as cerebral fat embolism (CFE).</span><span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Case Presentation:</span></i></b><span lang="EN"> We report a case of successfully treated SCD patient suffering from non-traumatic cerebral fat embolism (NCFE) who came with initial manifestation of localized pain followed by loss of consciousness and absence of cardiac shunt. </span></span><br> <span style="line-height:14pt"><span lang="EN">This was an unusual case of fat embolism in SCD patient with the absence of right-to-left cardiac shunt indicating the biochemical etiology. Patient initially showed localized pain followed by loss of consciousness, suggesting that any such initial manifestation in patient of SCD should be suspected for CFE. MRI served as an accurate diagnostic tool showing the characteristic neuroradiologic sign. Treatment with exchange-transfusion recovered the patient successfully. </span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Overall, this case suggested that prompt diagnosis using MRI and treatment with RBC exchange could lead to better outcomes in SCD patients suffering from CFE.<b><i><span style="color:#0033cc"></span></i></b></span></span></span> Cerebral Fat Embolism, Sickle-cell Disease, Starfield Appearance, Non-traumatic cerebral fat embolism 143 146 http://caspjim.com/browse.php?a_code=A-10-2301-1&slc_lang=en&sid=1 Ahmad Almatar Ahmadalmatar@gmail.com 100319475328460040894 100319475328460040894 Yes Department of Neurology, King Fahad Hospital of The University, Khobar, Saudi Arabia Kawther Hadhiah khadhiah@yahoo.com 100319475328460040895 100319475328460040895 No Neurocritical Care, King Fahad Hospital of The University, Khobar, Saudi Arabia