en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Various ways of treating H.pylori infection are reported, such as triple-therapy and quadruple therapy for two weeks. Some side effects have been seen during these treatments, besides Helicobacter pylori becoming resistant to these antibiotics easily. According to some studies, there is a relationship between metformin and reduction in Helicobacter pylori infection. Thus, in this study, we determine the effects of metformin on Helicobacter pylori infection.<span style="font-size:9.0pt"></span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> We performed this assessment in a randomized, case-controlled way in the diagnosis of Helicobacter pylori infected outpatients and inpatients. In both groups (case group and control group), patients took two tablets for a two-week period. In the case group, the patients were given two metformin tablets (each containing 500mg of metformin (extended release) and in the control group, they were given two placebo tablets (each containing 500mg of white flour). We took h.pylori Ag stool test and rapid urease test to confirm the presence of Helicobacter pylori infection.<i><span style="font-size:10.0pt"></span></i></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> In this study, at first all the patients had positive h.pylori Ag stool test or positive rapid urease test. At the end of this study, the results of h.pylori Ag stool*- test presented that Helicobacter pylori infection was negative in 82.7% of the case group patients and 76% of control group patients which illustrates suppression of Helicobacter pylori infection. However, comparing to the control group (P=0.36), this difference was not statistically remarkable.<b><i><span style="color:blue"></span></i></b></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> According to these findings, it is stated that having metformin along with prescribed antibiotics can help decrease Helicobacter pylori infection.<b><i><span style="color:#0033cc"></span></i></b></span></span></span> Helicobacter Pylori eradication, metformin, Helicobacter Pylori infection 567 574 http://caspjim.com/browse.php?a_code=A-10-2273-1&slc_lang=en&sid=1 Shahriar Nikpour nikpour@sbmu.ac.ir 100319475328460037567 100319475328460037567 No Internal Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Salehi m.salehi92@yahoo.com 100319475328460037568 100319475328460037568 No Internal Ward, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Sina Homaee sina.homaee@gmail.com 100319475328460037569 100319475328460037569 Yes Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Farnaz Saberian farnazsaberian@gmail.com 100319475328460037570 100319475328460037570 No Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Saeid Kalbasi saeid_kalbasi@yahoo.com 100319475328460037571 100319475328460037571 No Department of Internal Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran