Caspian Journal of Internal Medicine

en Evaluation of serum C4d levels in patients with systemic lupus erythematosus and its relation to lupus nephritis Reumatology Reumatology Original Article Original Article Background: Lupus nephritis (LN) is a debilitating complication of systemic lupus erythematosus (SLE). Renal biopsy is the gold standard for evaluating LN. Serum C4d is a potential non-invasive method for evaluating LN. The purpose of this study was to evaluate the value of C4d in the assessment of LN. Methods: This cross-sectional study was conducted on patients with LN who were referred to a tertiary hospital in Mashhad, Iran. Subjects were divided into four groups including LN, SLE without renal involvement, chronic kidney disease (CKD) and healthy controls. Serum C4d. creatinine, and glomerular filtration rate (GFR) were assessed for all subjects. Results: Forty-three subjects (11, 25.6% healthy controls, 9, 20.9% SLE patients, 13, 30.2% LN and 10, 23.3% CKD patients) participated in this study. CKD group were significantly older than other groups (p>0.05). There was a significant difference in gender distribution between groups (p<0.001). Median serum C4d were 0.6 in healthy controls and CKD group and 0.3 in SLE and LN groups. There was no significant difference in serum C4d between groups (p=0.503). Conclusion: The findings of this study indicated that serum C4d might not be a promising marker in the assessment of LN. These findings should be documented by further multicenter studies. Lupus nephritis, Systemic lupus erythematosus, C4d 231 236 http://caspjim.com/browse.php?a_code=A-10-2221-1&slc_lang=en&sid=1 Nayyereh Saadati saadatin@mums.ac.ir 100319475328460042526 100319475328460042526 No Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Miri mirighm@mums.ac.ir 100319475328460042527 100319475328460042527 Yes Kidney transplantation complication research center,Mashhad university of medical sciences,mashhad,Iran