en Oncology Oncology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0000ff;"><em><strong>Background:</strong></em></span> Radiodermatitis is the most common complication of radiotherapy. There is no gold standard for managing the radiodermatitis. This study aimed to evaluate the effect of topical Recove^&reg; burn ointment; basically compounded of sesame oil, camphor, and zinc oxide; in preventing acute radiodermatitis.<br> <span style="color:#0000ff;"><em><strong>Methods:</strong></em></span> This double blind RCT (IRCT No.: 201204047136N2) was performed on 71 patients that referred for radiotherapy after mastectomy to Shahid Rajaee Hospital (Babolsar-Iran) during 2013-2017. Patients were allocated into 2 groups; 34 in control group and 37 in Recove^&reg; group. Patients applied the ointment 2 times a day, before every radiation therapy session for 5 weeks. The radiation oncologist assessed the severity of dermatitis weekly for 5 weeks and graded it from 0 to 4 according to the RTOG criteria.<br> <em><span style="color:#0000ff;"><strong>Results:</strong></span></em>Baseline characteristics including age, and BMI had no significant difference between groups. The Recover group patients experienced significantly less severe dermatitis compared to the controls (p<0.001). None of the patients in Recove&reg; group encountered more than grade 2 of RTOG criteria, however, in the control group, 4 (12.9%)patients experienced grade 3 of RTOG and 3 (9.7%)patients developed grade 4 of RTOG at the end of the 5^th week.<br> <em><span style="color:#0000ff;"><strong>Conclusion:</strong></span></em> Our results indicate that Recove^&reg;ointment significantly reduces the severity of acute radiodermatitis.</span></span> breast cancer, radiotherapy, radiodermatitis, Recove ointment, radiation therapy oncology group. 349 355 http://caspjim.com/browse.php?a_code=A-10-2034-1&slc_lang=en&sid=1 Nargeuss Abbaszade Marzbali n.abbaszade@gmail.com 100319475328460036505 100319475328460036505 No Babol University of Medical Sciences Ebrahim Zabihi e_zabihi@yahoo.com 100319475328460036506 100319475328460036506 No Babol University of Medical Sciences Nicolas Magne nicolas.magne@icloire.fr 100319475328460036507 100319475328460036507 No Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France Alexis Vallard alexis.vallard@icloire.fr 100319475328460036508 100319475328460036508 No Department of Radiotherapy, Lucien Neuwirth Cancer Institute, Saint-Priest en Jarez, France Mohammad Moslemi mmoslemi77777@yahoo.com 100319475328460036509 100319475328460036509 No Babol University of Medical Sciences Dariush Moslemi moslemi_d@yahoo.com 100319475328460036510 100319475328460036510 Yes Babol University of Medical Sciences