en Internal Internal Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background</em></strong><em>:</em></span> Dyslipidemia has been reportedly associated with an increased risk of atherosclerosis among psoriatic patients. Dietary intake can be a key factor in the pathophysiology of psoriasis. Herein, we assessed serum lipid profile and dietary intake in psoriatic patients, in comparison with healthy subjects.<br> <span style="color:#0033ff;"><strong><em>Methods</em></strong><em>:</em> </span>In this case-control study, 45 psoriatic patients and 43 healthy controls were evaluated. We estimated the macro/micronutrient intakes and energy, using a food frequency questionnaire (FFQ). Anthropometric parameters and serum levels of triglyceride (TG), high-density lipoproteins (HDL), low-density lipoproteins (LDL), and very low-density lipoproteins were assessed. The case group was categorized by severity measured by PASI score (mild<10, moderate 10-20, severe >20). Diet plan 6.0 was used to analyze FFQs and data were analyzed in SPSS 16.0, with p<0.05 considered significant.<br> <span style="color:#0033ff;"><strong><em>Results</em></strong><em>:</em></span> The case group had markedly higher body mass index (BMI), LDL, and cholesterol and significantly lower HDL compared with controls (p<0.05). Carbohydrate, energy, fat intakes were significantly higher in cases, while folate, fiber, and vitamin E intakes were significantly lower in the case group, compared with the control group (p<0.05). BMI, cholesterol, and triglyceride values and dietary intakes of fiber and vitamin E were significantly associated with severity of psoriasis (p<0.05).<br> <span style="color:#0033ff;"><strong><em>Conclusion</em></strong><em>:</em> </span>Serum lipid profile and dietary intake are substantially important in psoriasis severity. Therefore, close monitoring of lipid profile and BMI during admission and follow-up and dietary modification can improve the severity of psoriasis.</span></span> psoriasis, FFQ, lipid profile, oxidative stress, BMI, PASI score 606 612 http://caspjim.com/browse.php?a_code=A-10-1773-1&slc_lang=en&sid=1 Mohammad Javad Yazdanpanah YazdanpanahMJ@mums.ac.ir 100319475328460032170 100319475328460032170 No Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Sadegh Vahabi-Amlashi VahabiS@mums.ac.ir 100319475328460032171 100319475328460032171 No Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mohsen Nematy nematym@mums.ac.ir 100319475328460032172 100319475328460032172 No Department of Nutrition and Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Neda Shaelaei n.shalaei@gmail.com 100319475328460032173 100319475328460032173 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Seyed Amir Reza Mohajeri s.a.r.mohajery@gmail.com 100319475328460032174 100319475328460032174 No Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Tafazzoli TafazzoliZ951@mums.ac.ir 100319475328460032175 100319475328460032175 Yes Cutaneous Leishmaniasis Research Center, Mashhad University of Medical Sciences, Mashhad, Iran