en Biochimestry Biochimestry Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background</em></strong><em>:</em></span> Parkinson&#39;s disease (PD) is defined as a long-lasting, neurological illness. Low levels of serum lipid fractions are related with a high risk of PD. Current investigation was designed to evaluate the concentration blood lipid fractions in patients suffering from PD and compared with healthy subjects.<br> <span style="color:#0033ff;"><strong><em>Methods</em></strong><em>:</em></span> This case-control study was conducted from February 2016 to September 2018 in Tabriz University of Medical Sciences, Tabriz, Iran. The present investigation consisted of 75 persons who had PD and 75 normal people. The blood levels of lipid fractions were measured by concentrations of total cholesterol (TC), serum triglycerides (TG), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), and total cholesterol. The results were analyzed with SPSS software using Kolmogorov-Smirnov, chi-square, and student&#39;s t-test.<br> <span style="color:#0033ff;"><strong><em>Results</em></strong><em>:</em></span> Serum level of TG was remarkably lower in patients with PD (111.92&plusmn;8.75 mg/dL) compared with healthy subjects (123.64&plusmn;9.97 mg/dL, P=0.008).&nbsp; Furthermore, we saw an important difference in the level of LDL-C (P=0.001) and TC (P=0.004) between the two groups. However, there was not any observed meaningful difference in the serum concentrations of HDL-C between the studied groups (P=0.135).<br> <span style="color:#0033ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Our results showed that the serum concentration of TG, LDL-C, and TC are noticeably lower in the PD suffering patients. Further investigations are needed to provide comprehensive information on the participants&#39; cognitive layout and subsequent actions.</span></span> Triglycerides, LDL, HDL, Cholesterol, Parkinson Diseases 155 161 http://caspjim.com/browse.php?a_code=A-10-71-7&slc_lang=en&sid=1 Samira Saedi samirasaedi18@yahoo.com 100319475328460028146 100319475328460028146 Yes Department of Medicine Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran Mohsen Hemmati-Dinarvand mohsen_h43@yahoo.com 100319475328460028147 100319475328460028147 No Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Haleh Barmaki Hale.barmaki@gmail.com 100319475328460028148 100319475328460028148 No Shahid Beheshti University of Medical Sciences, Tehran, Iran. Zohreh Mokhtari mokhtari45@gmail.com 100319475328460028149 100319475328460028149 No Department of Laboratory Medicine, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran Hadis Musavi msc.musavi66@gmail.com 100319475328460028150 100319475328460028150 No Student Research Committee, Babol University of Medical Sciences, Babol Iran Mohamad Valilo mohamsd_valiloo@gmail.com 100319475328460028151 100319475328460028151 No Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Ali Mota alimota.bio@yahoo.com 100319475328460028152 100319475328460028152 No Department of Clinical Biochemistry and Laboratory Medicine, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Soleiman Mahjoub smahjoub20@gmail.com 100319475328460028153 100319475328460028153 No Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran