en Anesthesiology Anesthesiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background</em></strong><em>:</em></span> The aim of this study was to compare the analgesic effects of pregabalin and ketamine on reducing pain after abdominal hysterectomy.<br> <span style="color:#0033ff;"><strong><em>Methods</em></strong><em>:</em></span> In this double-blind clinical trial, one hundred forty ASA I and II patients of age range 30-60 years scheduled for abdominal hysterectomy undergoing general anesthesia in 2018, were randomly divided into 4 equal groups. Pregabalin group received 300 mg oral pregabalin, ketamine group received 0.3 mg/kg of intravenous ketamine, and pregabalin- ketamine group received the combination of the two-above medication, and placebo group received the placebo and saline. Patients were evaluated for pain intensity according to the visual analogue scale (VAS) at 2, 4, 6, 12, 18, and 24 hours after surgery. Also, the need for analgesic drugs and the frequency of repetitions were also recorded. Statistical analysis was performed using STATA, Version 14. A p- value less than 0.05 was considered statistically significant.<br> <span style="color:#0033ff;"><strong><em>Results</em></strong><em>:</em></span> In the pregabalin and pregabalin-ketamine groups, pain in the first 6 hours after the end of operation was significantly less than the other two groups (p<0.05), but there was no significant difference between the 4 groups at 18 and 24 hours after surgery. The need for analgesic medications in the pregabalin group was lower than in other groups (p<0.05).<br> <span style="color:#0033ff;"><strong><em>Conclusion</em></strong><em>:</em></span> The results of this study show that the administration of oral pregabalin with and without intravenous ketamine before abdominal hysterectomy can decrease postoperative pain and reduce the need for analgesia.</span></span> Pregabalin, Ketamine, Pain, Hysterectomy. 217 222 http://caspjim.com/browse.php?a_code=A-10-1713-1&slc_lang=en&sid=1 Negin Ghadami ghadaminegin@gmail.com 100319475328460028191 100319475328460028191 Yes Department of Anesthesiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran Farzad Sarshivi Farzadsarshivi@gmail.com 100319475328460028192 100319475328460028192 No Department of Anesthesiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran Arvin Barzanji arvin.barzanji1988@gmail.com 100319475328460028193 100319475328460028193 No Department of Anesthesiology, Faculty of Paramedical, Kurdistan University of Medical Sciences, Sanandaj, Iran Bijan Nouri bijannuri@gmail.com 100319475328460028194 100319475328460028194 No Social Determinants of Health Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran Zahra Mohammadi zm141570@gmail.com 100319475328460028195 100319475328460028195 No Department of Anesthesiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran