en Radiology Radiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background</em></strong><em>:</em></span> Decreasing signal intensity of the spleen assessed by T2* MRI is a frequent finding in patients with beta-thalassemia due to iron deposition within the reticuloendothelial cells in this organ. This parameter can also be applied to determine the candidates for blood cell transfusion. However, the association between splenic siderosis and iron overload in other vital organs such as heart and liver remains unclear. The present study aimed to assess the correlation between iron deposition in splenic, hepatic and myocardial tissues by T2* relaxometry technique.<br> <span style="color:#0033ff;"><strong><em>Methods</em></strong><em>:</em></span> This cross-sectional study included 39 consecutive patients with a definitive diagnosis of beta-thalassemia major who underwent spleen, liver and heart MRI examinations for iron deposition and cardiac function.<br> <span style="color:#0033ff;"><strong><em>Results</em></strong><em>:</em></span> No significant correlation was found between the heart and splenic T2* relaxation time (R=0.206, P=0.357). We revealed a strong correlation between the splenic T2* relaxation time and hepatic calculated T2*s (R=0.515, P=0.014). The liver T2* values can be predicted from the splenic T2*s by a new linear equation. According to the ROC curve analysis, the splenic T2* could significantly, but moderately predict moderate to severe from mild liver iron excess (AUC=0.667).<br> <span style="color:#0033ff;"><strong><em>Conclusion</em></strong><em>:</em></span> Our study demonstrated a significant linear correlation between the splenic and hepatic T2* relaxation time, probably indicative of the same iron deposition mechanism, and made us available to write a linear model that would predict the deposited iron density in the spleen with&nbsp; the use of the magnetic resonance T2* values.</span></span> Magnetic Resonance Imaging, T2* Mapping, Spleen, Beta-Thalassemia, Iron Concentration 600 605 http://caspjim.com/browse.php?a_code=A-10-1673-1&slc_lang=en&sid=1 Ali Mohammadzadeh mralimohammadzadeh@yahoo.com 100319475328460032166 100319475328460032166 No Iran University of Medical Sciences, Rajaie Hospital, Tehran, Iran Saeed Alizadeh gonall100@yahoo.com 100319475328460032167 100319475328460032167 No Department of Radiology,Iran University of Medical Sciences, Rajaie Hospital, Tehran, Iran Layla Shojaie shojaie.layla@gmail.com 100319475328460032168 100319475328460032168 No Tehran University of Medical Sciences, Tehran, Iran Maryam Mohammadzadeh mm1361@yahoo.com 100319475328460032169 100319475328460032169 Yes Tehran University of Medical Sciences, Tehran, Iran