en Internal Internal Original Article Original Article <span style="font-size: 14px;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background</em></strong><em>:</em> </span>Among the inflammatory factors, high-sensitivity C-reactive protein (hs-CRP) is one of the strongest predictors of cardiovascular disease. This study aimed to evaluate the relationship of serum hs-CRP level with shift work among reproductive age women.<br> <span style="color: rgb(0, 0, 255);"><strong><em>Methods</em></strong><em>:</em></span> This cross-sectional study was conducted from September 2017 to May 2018 in three cities in Mazandaran Province, North of Iran. Through purposive sampling, 350 women (172 shift workers and 178 day workers) were recruited. The guideline recommended by the American Heart Association and the Centers for Disease Control and Prevention was used to interpret the result of hs-CRP measurement as the following: less than 1 &micro;g/ml: low CVD risk; 1&ndash;3 &micro;g/ml: moderate CVD risk; and more than 3 &micro;g/ml: high CVD risk. The data were analyzed using the independent-sample t and the chi-square tests as well as the logistic regression analysis.<br> <span style="color: rgb(0, 0, 255);"><strong><em>Results</em></strong><em>:</em> </span>11.1% of participants had a serum hs-CRP level of more than 3 &micro;g/ml. This rate among shift workers was significantly greater than day workers (15.6% vs. 7.0%; p=0.012). After adjusting the effects of potential confounders shift work significantly increased the odds of serum hs-CRP level of more than 3 &micro;g/ml by 2.45 times (OR=2.45, 95% CI: 1.01&ndash;5.93, p=0.047).<br> <span style="color: rgb(0, 0, 255);"><strong><em>Conclusion</em></strong><em>:</em> </span>Shift work is a significant predictor of high serum hs-CRP level probably due to its association with sleep problems and occupational stress. Improving the knowledge of female shift workers about the importance of quality sleep can reduce their CVD risk and improve their health.</span></span> Shift work, Reproductive age, High-sensitivity C-Reactive Protein, Cardiovascular disease, Women 402 410 http://caspjim.com/browse.php?a_code=A-10-1412-1&slc_lang=en&sid=1 Maryam Nikpour Maryamnikpour19@yahoo.com 100319475328460018827 100319475328460018827 No Student Research Committee, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Aram Tirgar a.tirgar@mubabol.ac.ir 100319475328460018828 100319475328460018828 Yes Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR. Iran. Behzad Heidari bheidari6@gmail.com 100319475328460018829 100319475328460018829 No Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Abbas Ebadi ebadi1347@yahoo.com 100319475328460018830 100319475328460018830 No Behavioral Sciences Research Center, Life style institute, Nursing Faculty, Baqiyatallah University of Medical Sciences, Tehran, Iran Fatemeh Ghaffari ghafarifateme@yahoo.com 100319475328460018831 100319475328460018831 No Nursing Care Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Akram Hosseini dr_hosseini_2006@yahoo.com 100319475328460018832 100319475328460018832 No Clinical Research Development Center, Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran