Caspian Journal of Internal Medicine

en The efficacy of addition of dexmedetomidine to intrathecal bupivacaine in lower abdominal surgery under spinal anesthesia Anesthesiology Anesthesiology Original Article Original Article Background: Spinal anesthesia is the common choice for anesthesia in lower abdomen surgery and intrathecal adjutants have gained popularity with the aim of prolonging the duration of block, quality of block and post operation pain control. The purpose of this study was to evaluate the effects of adding dexmedetomidine to hyperbaric bupivacaine in lower abdominal surgery under spinal anesthesia. The main outcomes were considered pain score, duration of analgesia, hemodynamic changes and adverse side effects like nausea and vomiting. Methods: This double-blind randomized clinical trial was conducted on one hundred patients between 18 to 65 years old scheduled for lower abdominal surgery. Fifty patients were randomly allocated to receive either 12.5mg hyperbaric bupivacaine (2.5cc) plus 5µgr dexmedetomidine (0.5cc) intrathecally while fifty patients received either 12.5mg hyperbaric bupivacaine (2.5cc) and 0.5cc Saline 0.9% intrathecally. Results: Vital sign parameters like heart rate, blood pressure and oxygen saturation levels were registered in the normal range in both groups. The average duration of the onset of pain (230±86 min) in bupivacaine group was significantly (p≤0.000) less than dexmedetomidine group (495±138 minutes). The severity of pain at all times in dexmedetomidine group was significantly (p<0.05) less than bupivacaine group. The severity of shivering and the number of patients who needed treatment for nausea and vomiting in dexmedetomedine group has been less in comparison to bupivacaine. Conclusion: We concluded that intrathecal dexmedetomidine increases the duration of analgesia and reduces postoperative pain without changes in the hemodynamic parameters and adverse side effects. It can be considered as an appropriate adjuvant to intrathecal local anesthetics for lower limb surgeries. Dexmedetomidine, Bupivacaine, analgesia, Spinal anesthesia. 142 149 http://caspjim.com/browse.php?a_code=A-10-848-1&slc_lang=en&sid=1 Milad Minagar m3078m@gmail.com 100319475328460016783 100319475328460016783 Yes Department of Anesthesiology and Critical Care Medicine, Tehran University of Medical Sciences, Tehran, Iran Ebrahim Aliganpour m3078m@gmail.com 100319475328460016784 100319475328460016784 No Department of Anesthesiology and Critical Care Medicine, Babol University of Medical Sciences, Babol, Iran Ali Jabbari m3078m@gmail.com 100319475328460016785 100319475328460016785 No Department of Anesthesiology and Critical Care Medicine, Golestan University of Medical Sciences, Gorgan, Iran Seyed Mozaffar Rabiee m3078m@gmail.com 100319475328460016786 100319475328460016786 No Department of Anesthesiology and Critical Care Medicine, Babol University of Medical Sciences, Babol, Iran Nadia Banihashem m3078m@gmail.com 100319475328460016787 100319475328460016787 No Department of Anesthesiology and Critical Care Medicine, Babol University of Medical Sciences, Babol, Iran Parviz Amri m3078m@gmail.com 100319475328460016788 100319475328460016788 No Department of Anesthesiology and Critical Care Medicine, Babol University of Medical Sciences, Babol, Iran Mehrafza Mir m3078m@gmail.com 100319475328460016789 100319475328460016789 No Department of Anesthesiology and Critical Care Medicine, Babol University of Medical Sciences, Babol, Iran Mohammad Taghi Hedayati Goudarzi m3078m@gmail.com 100319475328460016790 100319475328460016790 No Department of Cardiology, Babol University of Medical Sciences, Babol, Iran Mohammad Esmaeili m3078m@gmail.com 100319475328460016791 100319475328460016791 No Department of Anesthesiology and Critical Care Medicine, Babol University of Medical Sciences, Babol, Iran