en Hematology Hematology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong></span> Bone lesion in multiple myeloma (MM) is most commonly presented as a lytic lesion in this disease. Determination of extent of bone lesions in MM is necessary to follow-up the patients. Whole body bone scan with 99m, Tc-methylene diphosphonate (MDP) has a lower sensitivity than other modalities.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> From the patients with MM admitted to Ayatollah Rouhani Hospital of Babol-Iran from 2009 to 2015, who had undergone whole body bone scan during diagnostic process, were entered into the study. Findings of bone scan were compared with MRI.<br> <span style="color:#0000FF;"><strong><em>Results:</em></strong></span> Of the 19 patients, sixteen (84.2%) of them had positive finding in bone scan, fifteen (78.9%) had MRI of the spine. While of the thirteen patients who had positive finding in MRI, seven (53.8%) had more positive finding in thorcolumbosacral MRI than in bone scan.<br> <span style="color:#0000FF;"><strong><em>Conclusions:</em></strong></span> 99m-Tc MDP bone scan is a sensitive but insufficient method for detecting bone lesions in MM.</span></span><br> <p align="right" dir="RTL"></p> Tc-99m methylene diphosphonate, bone lesion, multiple myeloma 140 143 http://caspjim.com/browse.php?a_code=A-10-117-1&slc_lang=en&sid=1 Mohsen Vakili-sadeghi mvakili89@gmail.com 100319475328460011949 100319475328460011949 Yes Babol university of medical sciences2. Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Sadegh Sedaghat sadeghsedaghat@yahoo.com 100319475328460011950 100319475328460011950 No Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran