en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><span style="line-height:150%"><span style="color:#0033ff;"><strong><em>Background:</em></strong></span> Pancreatic cancer is among the deadliest malignancies globally, marked by poor prognosis and limited survival. This research investigated the demographic and clinical determinants affecting overall survival in patients diagnosed with pancreatic cancer in Guilan Province, Iran.</span></span><br> <span style="line-height:150%"><span style="line-height:150%"><span style="color:#0033ff;"><em><strong>Methods:</strong></em></span> A total of 50 pathologically and radiologically confirmed cases of pancreatic cancer were analyzed. Demographic, anthropometric, and clinical data were extracted from medical records. Survival probabilities were estimated using the Kaplan&ndash;Meier method, and intergroup differences were tested using the log-rank test. Cox proportional hazards modeling identified predictors of mortality, with significance defined at <i>p</i> < 0.05. Statistical analyses were conducted in SPSS (Version 16)</span> <span style="line-height:150%">and GraphPad Prism (v8).</span></span><br> <span style="line-height:150%"><span style="line-height:150%"><strong><em><span style="color:#0033ff;">Results:</span></em></strong> The majority of patients were males (60%) and over 60 years old (58%), while 46% had normal BMI and 40% had blood group O. Comorbidities were present in 42%, and 32% were diagnosed at stage IV. Mean and median survival were 39.6 and 9.0 months, respectively. One-, three-, and five-year survival rates were 45.2%, 31.3%, and 23.5%. Advanced tumor stage (III/IV) significantly predicted shorter survival (p < 0.001). Underweight individuals had higher mortality risk (HR = 2.79; 95% CI: 1.21&ndash;6.42; P = 0.016). In multivariate models, male gender, blood group O, and advanced disease remained independent negative prognostic indicators.</span></span><br> <span style="line-height:150%"><span style="line-height:150%"><em><strong>Conclusion:</strong></em> Male sex, advanced stage, low BMI, and blood group O were major determinants of poorer survival in pancreatic cancer. These results emphasize the need for individualized treatment and closer follow-up among high-risk groups.</span></span><br> <span style="line-height:150%"><span style="line-height:150%"><span style="color:black"></span></span></span></span></span><br> &nbsp; Pancreatic cancer, Survival determinants, Prognostic factors, Tumor stage 22 0 http://caspjim.com/browse.php?a_code=A-10-3846-1&slc_lang=en&sid=1 Mohammad Almasi Dr_m.almasi@yahoo.com 100319475328460056511 100319475328460056511 Yes Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Niloofar Faraji niloofarfaraji.sci@gmail.com 100319475328460056512 100319475328460056512 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Farahnaz Joukar farajov@gmail.com 100319475328460056513 100319475328460056513 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Narges Eslami Negareslami070@gmail.com 100319475328460056514 100319475328460056514 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Saman Maroufizadeh Saman.maroufizadeh@gmail.com 100319475328460056515 100319475328460056515 No Department of Biostatistics, School of Health, Guilan University of Medical Sciences, Rasht, Iran Amineh Hojati amineh.hojati.gi@gmail.com 100319475328460056516 100319475328460056516 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran Fariborz Mansour-Ghanaei fmansourghanaei@gmail.com 100319475328460056517 100319475328460056517 No Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran