en Gastroentrology Gastroentrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><strong><em>Background:</em></strong></span> This paper aims to compare Survival of gastric cancer patients with neoadjuvant chemotherapy versus direct surgery. The present research assesses the 36-month survival of gastric cancer patients treated in our center with and without NAC and overall 36-month survival.<br> <span style="color:#0033ff;"><em><strong>Methods:</strong></em></span> The present research assesses the 36-month survival of gastric cancer patients treated in our center with and without NAC and overall 36-month survival. 79 patients entered this study, of whom 64 received NAC and 15 underwent direct surgery.&nbsp;<br> <strong><em><span style="color:#0033ff;">Results:</span></em></strong> Generally, the three-year survival rate in the groups was statistically different based on the Wilcoxon test (P 0.004). NAC was effective in increasing survival in the groups with Lymph o vascular invasion, higher stage and all pathologic groups. However, age, type of surgery (TG vs DG), number of positive lymph nodes, and positive margin after surgery were not effective in interfering with survival in both groups. Neoadjuvant chemotherapy can positively increase OS and DFS in locally advanced gastric cancer. NAC was effective in increasing survival in the groups with Lymph o vascular invasion, higher stage and all pathologic groups.&nbsp;<br> <span style="color:#0033ff;"><strong><em>Conclusion:</em></strong></span> Considering the similar results in previous studies, larger prospective studies with accurate information can effectively achieve definitive results. However, age, type of surgery (TG vs DG), number of positive lymph nodes, positive margin after surgery were not effective interfering with survival in both groups.</span></span> Gastric cancer, Survival, Chemotherapy. 13 0 http://caspjim.com/browse.php?a_code=A-10-3742-2&slc_lang=en&sid=1 Vahid Zangouri zangouri.vahid1390@gmail.com 100319475328460056461 100319475328460056461 No Breast Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Masoumeh Molanorouzi Dr.masi.m.norouzi@gmail.com 100319475328460056462 0009-0008-3911-5282 No Department of surgery, Semnan University Of Medical Sciences, Semnan, Iran Saba Ebrahimian saba_ebr@yahoo.com 100319475328460056463 100319475328460056463 Yes Department of surgery, Babol University Of Medical Sciences, Babol, Iran