en Gastroentrology Gastroentrology case report case report <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><span style="unicode-bidi:embed"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Background:</span></b></em></span><span style="line-height:150%"> The Strongyloides genus of nematodes, notably Strongyloides stercoralis, serves as significant parasites affecting terrestrial vertebrates, including humans. These parasites have a complex life cycle that alternates between free-living and parasitic stages, resulting in various clinical manifestations that frequently present with non-specific symptoms. Strongyloidiasis, the condition caused by these parasites, primarily occurs in tropical and temperate regions, where infective larvae can penetrate human skin to establish infections.</span></span></span><br> <span style="line-height:150%"><span style="unicode-bidi:embed"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Case Presentation:</span></b></em></span><span style="line-height:150%"> This report presents a 78-year-old male patient who experienced progressive lower limb edema over four months. Considerable accompanying symptoms included functional class II dyspnea, night sweats, fever and chills, nausea, lethargy, and a significant weight loss of 20 kg over eight months. After clinical workups, the pathology report and diagnostic stool examinations confirmed the presence of Strongyloides stercoralis larvae. The patient was treated with Albendazole for seven days, resulting in a complete alleviation of all symptom in follow-up period.</span></span></span><br> <span style="line-height:150%"><span style="unicode-bidi:embed"><em><span style="color:#0033ff;"><b><span style="line-height:150%">Conclusion:</span></b></span></em><span style="line-height:150%"><em> </em>This case report highlights the necessity of increasing awareness of strongyloidiasis, particularly in elderly patients with non-specific systemic symptoms in endemic regions. The effective treatment of this patient with Albendazole demonstrates the importance of timely antiparasitic therapy in alleviating symptoms and preventing complications associated with Strongyloidiasis. Clinicians should maintain suspicion and include this infection in differential diagnoses of protein-loss enteropathy. Enhanced diagnostic efforts and prompt treatment are essential to mitigate the risks of this neglected tropical disease, especially in vulnerable populations. </span></span></span><br> &nbsp;</span></span> Key words: Strongyloides Stercoralis, Strongyloidiasis, Protein-loss enteropathy 25 0 http://caspjim.com/browse.php?a_code=A-10-3558-1&slc_lang=en&sid=1 Faezeh Firuzpour Faezeh.1997@gmail.com 100319475328460056537 0009-0007-5826-0314 No Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Pedram Beigvand Faezeh.1997@gmail.com 100319475328460056538 0009-0008-8037-5027 Yes Babol university of medical sciences and health services, Babol, Iran Niloofar Moradi dr.moradi1369@gmail.com 100319475328460056539 0009-0003-2508-743X No Babol University of Medical Sciences and Health Services, Babol, Iran Hadis Zaboli hadis.zabolii@gmail.com 100319475328460056540 0009-0008-1116-4779 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Fatemeh Jafarpour fatemehjafarpour955@gmail.com 100319475328460056541 0009-0003-2056-7039 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Zahra Naghdizadeh zahranaghdizadeh80@gmail.com 100319475328460056542 0009-0003-4263-3842 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Maryam Adabi marybabol81@gmail.com 100319475328460056543 0009-0005-3112-6137 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran